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Menopause Makeover

The menopause is a natural life stage, not a diagnosis. Yet the hormonal shifts around perimenopause and menopause can affect how you feel in your body and how you look in the mirror. A menopause makeover is a tailored, medical plan that blends lifestyle, hormone optimisation with your GP or specialist, and carefully chosen non-surgical and surgical treatments to address changes in skin, face, breasts, body, and intimate health. The goal is simple: help you feel more you again—healthy, energised, and confident—using safe, evidence-based care.

What actually changes at menopause?

Falling oestrogen and progesterone levels influence tissues all over the body:

Skin & hair: Collagen production drops and dermal thickness reduces, leading to dryness, dullness, fine lines, and more noticeable laxity around the jawline, neck, and arms. Some women notice acne flare-ups or increased facial hair due to relative androgen dominance.
Fat distribution & muscle: A tendency to central weight gain (abdomen, flanks) with reduced lean muscle mass and metabolic slowdown.
Breasts: Glandular tissue involutes and skin elasticity reduces, so breasts can deflate or descend, making previous bras fit poorly.
Pelvic & intimate health: Genitourinary syndrome of menopause (GSM) can cause vaginal dryness, laxity, discomfort with intercourse, and stress urinary leakage.
Energy, sleep, mood: Hot flushes, night sweats, brain fog, and sleep disturbance can sap motivation and affect training, diet, and recovery.

A menopause makeover recognises that these changes interact. Treating one area alone is rarely enough; redesigning your plan across hormones, lifestyle, skin, and shape often creates the most natural, long-lasting results.

Who is a good candidate?

You may benefit if you:

Are perimenopausal or postmenopausal and want a structured, safe plan to address multiple concerns at once.
Feel that diet and exercise alone are not shifting central fat or skin laxity.
Are medically well, a non-smoker (or committed to stopping), and have realistic expectations about risks, recovery and outcomes.
Prefer a single, coordinated approach with a consultant plastic surgeon and medical team guiding priorities and sequence.

If you have significant medical conditions (e.g., uncontrolled hypertension, cardiac disease, poorly controlled diabetes), you’ll need optimisation with your GP or specialist first—this is part of holistic care, not a barrier.

Step 1: Hormone & health optimisation (foundation first)

A truly effective makeover starts with your health:

HRT discussion with your GP or menopause specialist: Evidence suggests appropriately prescribed HRT can alleviate vasomotor symptoms, improve sleep and mood, and help maintain bone density. Transdermal oestrogen with micronised progesterone is commonly used in suitable candidates. Not everyone is eligible; individual benefits and risks must be assessed by your prescriber. Bioidentical hormone therapy Manchester is offered by our team at CLNQ.
Nutrition & body composition: A protein-forward, anti-inflammatory diet supports collagen and muscle. Strength training 2–3 times a week helps preserve lean mass and counters central fat gain.
Lifestyle upgrades: Sleep hygiene, stress management, and moderated alcohol intake meaningfully improve skin quality, energy, and recovery from procedures.
Supplement strategy (evidence-led): Vitamin D for bone health if deficient, omega-3 for cardiometabolic health, and topical retinoids for skin turnover—chosen case-by-case.

Why it matters: when hormones, sleep, and nutrition are steady, skin quality improves, swelling resolves faster, and surgical results look better, for longer.

Step 2: Non-surgical treatments that deliver

Many women prefer to start with no-downtime or minimal-downtime options. A personalised plan might include:

Skin quality & laxity

Medical-grade skincare: Prescription retinoids, pigment control, and barrier repair.
Energy-based rejuvenation:
- Microneedling RF / fractional RF for tightening crepey lower face/neck and improving pores and scars using Morpheus8.
- CO₂ fractional resurfacing for texture, wrinkles, and sun damage (longer downtime, bigger gains).
- Vascular lasers (e.g., PDL) for flushing/visible vessels often worse after hormonal shifts. The VBeam laser is a very good device for vascular lesions.
- Pigment lasers (e.g., Q-switched) or targeted peels for sun spots and melasma management. The Revlite is a good option for pigment treatment with laser.
Injectables:
- Hyaluronic acid fillers for strategic volume replacement (cheeks, chin, jawline, temples).
- Biostimulators (e.g., poly-L-lactic acid) to encourage collagen over months in lower face, jawline, and buttocks.
- Polynucleotides / skin boosters to hydrate and improve fine lines in thin, oestrogen-depleted skin.
- Anti-wrinkle treatments to soften dynamic lines while keeping expression natural.

Body contour & firmness

Body contouring with energy devices for modest fat pockets and skin laxity in abdomen, flanks, back rolls, arms, or thighs (options vary; results depend on candidacy).
Medical weight management via your GP or specialist if appropriate; plastic surgery is not a weight-loss tool, but contour surgery works best near a healthy, stable weight.

Intimate wellness

Pelvic floor rehabilitation & physiotherapy for stress incontinence and support.
GSM care with local oestrogen (via GP), lubricants, and, where appropriate, energy-based treatments focused on tissue quality.
Labiaplasty or labia puffing is sometimes requested for comfort and balanced aesthetics—discussed sensitively and tailored to anatomy.
FormaV is a radiofrequency device used for intimate wellness and helps with many symptoms.

Non-surgical therapies can be powerful alone or used to “pre-habilitate” the skin before surgery.

Step 3: Surgical options within a menopause makeover

When skin elasticity is limited and descent or redundancy is significant, surgery can achieve what devices cannot. The most requested procedures in this context include:

Face & neck

Lower face and neck lift: Repositions descended SMAS layers and tightens neck bands, reducing jowls and restoring a cleaner jawline with a discreet, hairline-friendly scar.
Eyelid surgery (blepharoplasty): Upper lid hooding and lower eye bags are common concerns; carefully planned blepharoplasty can open the eyes and refresh the midface.
Fat grafting (lipofilling): Restores soft, natural volume to temples, cheeks, nasolabial and marionette areas using your own fat, often alongside lifting.

Breasts

Mastopexy (breast uplift): Re-positions the nipple-areola complex and reshapes the breast envelope to address ptosis (droop).
Augmentation-mastopexy: Combines an implant with an uplift to restore both volume and position in one stage (case dependent).
Breast reduction: Relieves heaviness, neck/back discomfort, and improves proportions; many women report easier exercise and clothing choices after reduction.

Body

Abdominoplasty (tummy tuck): Removes redundant lower abdominal skin and can repair rectus diastasis (muscle separation), common after pregnancies; improves core function and contour.
Liposuction or lipoabdominoplasty: Targets stubborn fat in flanks, back, hips and mons; often combined with a tuck for a 360° silhouette.
Arm lift (brachioplasty): Addresses upper-arm laxity where skin quality limits the benefit of devices.
Thigh lift: For inner thigh laxity causing rubbing or difficulty with clothing.

Intimate surgery

Labiaplasty: For functional comfort and proportional aesthetics, performed with meticulous attention to sensitivity and healing.

Combining procedures: It’s common to pair a breast uplift with abdominal contouring (sometimes called a post-pregnancy or menopausal “makeover”). Safety dictates what can be combined in a single sitting; operative time, comorbidities, and DVT risk are carefully assessed.

Safety, risks, and recovery—clear and honest

Every intervention carries risk. Your consultation will include an individualised risk profile and consent process. General considerations:

Non-surgical: Temporary redness, swelling, bruising; rare issues include burns with energy devices, pigmentation change after lasers/peels (higher risk with recent sun exposure), vascular occlusion with fillers (minimised with expert technique and anatomy-led planning).
Surgery: Bleeding, infection, delayed wound healing, seroma, asymmetry, hypertrophic or keloid scarring (more likely in predisposed skin types), changes in nipple sensation after breast surgery, DVT/PE (reduced with protocol-led prophylaxis and early mobilisation).
Downtime snapshots (typical ranges):
- Anti-wrinkle: back to desk same day.
- Fillers/skin boosters: 1–3 days for swelling/bruise to settle.
- Fractional lasers: 5–7 days social downtime, redness may persist longer.
- Blepharoplasty: 7–10 days for most bruising to fade; light activities after 48–72 hours.
- Breast uplift/reduction: 10–14 days desk-based work; gym and lifting restrictions ~6 weeks.
- Abdominoplasty: 2 weeks light desk work if arranged, driving ~2 weeks when comfortable, core exercise from 6–8 weeks with guidance.

You receive detailed written aftercare, dressing support, and scheduled follow-ups to monitor healing and results.

Designing your menopause makeover: the pathway

Consultation & priorities: Share your health background, medications, prior treatments, and top three goals. High-definition photos and examination guide candidacy.
Health optimisation plan: Liaison with our GP/menopause specialist on HRT suitability and any pre-op optimisation (iron, vitamin D, blood pressure, glycaemic control). Longevity consultation for biomarker assessment and plan.
Treatment mapping:
- Sequence non-surgical (e.g., collagen stimulation) before any lifting surgery for best synergy.
- Time lasers/peels around events and sun exposure.
- Coordinate breast and body surgery if safe and beneficial to combine.
Cooling-off & consent: You’ll receive a written plan, pricing, expected recovery, risks, and realistic outcome ranges.
Procedure & aftercare: A doctor-led follow-up ensure consistent care.
Review & refine: Minor tweakments (e.g., skin boosters) may be planned after your tissues settle, enhancing longevity of results.

What results can you expect?

Most women report:

A fresher, well-rested facial appearance, with natural expression maintained.
Breasts sitting higher with better shape in clothing and swimwear; proportion improved.
A flatter abdomen with improved waist definition and posture; exercise feels easier.
Skin that looks healthier and more even, with fine lines softened and pores refined.
Enhanced comfort and confidence in intimate settings when intimate concerns are addressed.

Results evolve over weeks to months. Collagen-stimulating treatments continue to improve the dermis for up to 6–12 months. Surgical scars soften and fade over 12–18 months (scar quality varies by individual biology and care).

Why choose CLNQ for your Menopause Makeover?

Team approach: At CLNQ, we offer the whole range of treatments from medical assessments to surgical procedures. You can have your full menopause makeover with our team of specialists.
Aesthetic judgement: Subtle, proportionate changes—particularly in the face and breast—depend on precise analysis, not just technology.
Continuity of care: Pre-assessment, theatre, and aftercare remain within our specialist team.
Holistic integration: Your plan spans health, hormones, skin, shape, and sexuality—because confidence is multi-factorial.

Menopause makeover—treatment options

Your plan is bespoke, but these popular packages illustrate how elements combine:

The Skin-First Refresh

Prescription skincare, skin boosters or polynucleotides, fractional RF microneedling x3 sessions, and targeted pigment/vascular laser.
Ideal for: early perimenopause with texture concerns, fine lines, and colour irregularity.

Lift, Fill & Glow (Face)

Lower face/neck lift with conservative fat grafting to temples and midface, Facetite radiofrequency, followed by skin resurfacing after 8–12 weeks.
Ideal for: moderate jowls/neck laxity plus volume deflation.

Breast & Tummy Rebalance

Mastopexy or reduction with lipoabdominoplasty
Ideal for: breast ptosis/volume mismatch and central abdominal laxity.

Intimate Comfort & Confidence

Pelvic floor radiofrequency, oestrogen replacement with bioidentical hormone therapy, and labiaplasty for functional refinement when indicated.
Ideal for: dryness, chafing, visibility in clothing, discomfort with exercise.

Preparing for your makeover: practical tips

Weight stability: Aim for a stable, healthy weight for 3–6 months before surgery; large swings post-op can alter results.
Nicotine cessation: Stop smoking/vaping and nicotine replacement at least 6 weeks pre-op and post-op—critical for wound healing and scar quality.
Medication review: Some supplements and medicines increase bleeding risk; you’ll receive a personalised “pause list”.
Support network: Arrange help with school runs, pets, or heavy shopping in the first 1–2 weeks after larger procedures.
Sun strategy: Strict SPF and shade for 8–12 weeks after lasers/peels and on fresh scars to minimise pigmentation.
Scar care: Silicone gel/tape, massage techniques, and follow-ups to detect and manage problematic scarring early.

Frequently asked questions

Will I need HRT to do a menopause makeover?

Not necessarily. HRT is assessed and prescribed by your GP or menopause specialist. Many women choose non-surgical and surgical options with or without HRT. If you are on HRT, we coordinate peri-operative management with your prescriber.

How long do results last?

Ageing continues, but surgical lifting and contouring typically provide many years of benefit. Skin quality gains from biostimulators and lasers are maintained with good skincare, sun protection, and occasional maintenance sessions.

Can I combine breast and tummy surgery safely?

Often, yes, if your health status, BMI, and operative time remain within safe limits. Our surgeon will advise if staging is safer for you.

Is there an ideal age?

No single age. The right time is when concerns are persistent despite good lifestyle measures, and when the benefits outweigh downtime for your work and family life.

Will I have visible scars?

Yes—any surgery leaves scars. We plan incisions to be as discreet as possible, guide your scar aftercare, and monitor maturation. Scar visibility varies by individual biology.

What downtime should I expect?

Desk work is often possible within 1–2 weeks after breast and body procedures; driving returns when you’re safe to perform an emergency stop. Exercise usually resumes in phases over 6–8 weeks. Facial surgery bruising typically improves significantly by 2 weeks, with residual swelling settling over months.

How do I choose between fillers and fat grafting?

Fillers are adjustable with minimal downtime; fat grafting provides soft, living volume using your tissue, often done with lifts. The choice depends on areas treated, longevity goals, and your willingness for a short harvest procedure.

What are the main risks I should know about?

General surgical risks (bleeding, infection, DVT/PE), wound-healing issues, asymmetry, and dissatisfaction are discussed in detail at consent. Non-surgical risks include inflammation, pigment changes after lasers/peels, and vascular compromise with fillers (rare in expert hands).

Book your consultation

If you’re ready to explore a menopause makeover, the first step is a careful consultation to discuss your goals, assess candidacy, and design a plan that respects your health and lifestyle. You can book with our doctors for information about bioidentical hormones, longevity or aesthetics options. Our team of plastic surgeons will provide guidance on surgical options.

Final word

The menopause is a powerful transition. With a structured, team-led menopause makeover—rooted in health optimisation and evidence-based treatments—you can refresh your appearance and comfort, safely and naturally at CLNQ. Your plan is bespoke, your timeline is sensible, and your results are designed to look like you, on your very best day.

Droopy Eyelid After Botox

If you’ve noticed one eyelid sitting lower than the other after anti-wrinkle injections, you’re not alone. A “droopy eyelid” (medical term: blepharoptosis) is a known—thankfully temporary—side effect that occasionally occurs after Botox-type treatments. We explain what causes it, how long it lasts, the quickest ways to improve it, and practical steps you and your injector can take to prevent it next time.

Quick facts at a glance

What it is: Transient weakening of the eyelid-lifting muscle so the upper lid sits lower than usual.
Why it happens: Diffusion of toxin to the levator palpebrae superioris (the main eyelid-lifting muscle) or its supporting sympathetic muscle (Müller’s muscle) after injections in the frown/brow area.
How common: Uncommon; reported rates vary in studies because of injection sites and techniques, but it’s considered infrequent with modern methods.
Onset: Usually 2–10 days after treatment as the toxin effect develops.
Duration: Most cases improve gradually and resolve over 2–8 weeks (occasionally up to a full treatment cycle).
Best quick fixes: Prescription apraclonidine 0.5% or oxymetazoline 0.1% drops to stimulate Müller’s muscle and lift the lid by ~1–2 mm.
Other options under study: Off-label brimonidine 0.33% gel applied to the upper lid skin has been reported to help in some cases.
Prevention: Precise injection placement, conservative dosing, shallow injection planes where appropriate, and good aftercare (no rubbing/pressure, keep upright for 4 hours).

What exactly is a “droopy eyelid” after Botox?

Blepharoptosis means the upper eyelid margin sits lower than normal, sometimes partly covering the pupil. After aesthetic neuromodulator injections (e.g., Botox®, Azzalure®, Bocouture®, Dysport®), ptosis is most often related to treatments of the glabellar complex (frown lines) and, less commonly, the forehead. The problem arises when a small amount of toxin migrates from the intended muscle (corrugator/procerus) to the levator palpebrae superioris, temporarily weakening it. Another route is reduced tone of Müller’s muscle, which provides a subtle additional ~1–2 mm of eyelid lift via sympathetic fibres.

This is not the same as brow ptosis (when the eyebrow drops after over-relaxing the frontalis muscle). Brow ptosis makes the whole forehead feel heavy; eyelid ptosis specifically affects the lid margin. Differentiating the two matters because management differs.

Why does it happen in the first place?

Three key factors explain most cases:

Anatomy and proximity

The levator muscle and its aponeurosis sit just behind the orbital septum, close to common glabellar injection sites. If product is placed too low, too medially, too deep, or in large boluses, or if it’s massaged into surrounding areas, there’s a small risk of diffusion into the orbit affecting the levator.
Dose and dilution

Higher total dose, higher volume per point, and certain dilutions can increase spread. Experienced injectors adapt dose to anatomy and use appropriate volumes to reduce migration.
Aftercare and early pressure

Vigorous rubbing, pressure from tight headwear, lying flat immediately after treatment, or intense exercise/sauna on the day might contribute to product spread in the short “settling” window. Recommendations vary, but avoiding pressure and remaining upright for around 4 hours is standard prudence.

Additional contributors include individual tissue planes, previous surgery (e.g., blepharoplasty), and pre-existing subtle ptosis unmasked by treatment.

How long does a droopy eyelid last?

Because neuromodulators temporarily block the acetylcholine signal at the neuromuscular junction, the affected levator gradually regains function as new nerve terminals sprout and synaptic function recovers. Most aesthetic cases improve in 2–8 weeks, often much sooner when treated with adrenergic drops. Rarely, visible asymmetry can persist up to the usual toxin cycle (3–4 months), but that’s uncommon with modern techniques.

Symptoms you might notice

One eyelid looks lower, giving a “sleepy” appearance.
The eye may feel heavier or more tired, especially by evening.
Mild blur or visual field reduction if the lid covers the pupil (usually slight).
You may unconsciously recruit the brow (lifting the eyebrow) to clear the vision.

If you develop double vision, severe headache, sudden unequal pupils, or complete eyelid closure, seek urgent assessment to exclude non-cosmetic neurological causes—these are extremely rare but important to rule out.

How we improve a droopy eyelid quickly

At CLNQ (serving Botox Manchester and Cheshire patients), management is tailored and evidence-based:

Confirm the diagnosis

We assess eyelid position (MRD1), levator function, brow position, and forehead recruitment to distinguish eyelid ptosis from brow ptosis or true ophthalmic pathology.
Adrenergic eye drops (prescription)
- Apraclonidine 0.5% (1–2 drops t.i.d.) is widely used in practice to stimulate Müller’s muscle, creating a temporary lift of ~1–2 mm. Effects occur in minutes and last several hours. It’s off-label for toxin ptosis but supported by longstanding clinical use. Contraindications include certain glaucoma types and hypersensitivity; side effects can include eye irritation or dryness.
- Oxymetazoline 0.1% (Upneeq®) is MHRA/FDA-approved for acquired ptosis and improves MRD1 and superior visual field in trials; many clinicians use it for toxin-related cases. It’s typically one drop once daily (some use b.i.d.). Potential side effects include eye redness and dry eye.
Adjuncts and emerging options
- Topical brimonidine 0.33% gel to upper lid skin has been reported to elevate the lid transiently without ocular side effects in a small case report. Evidence is early and off-label.
- Simple measures such as taping are rarely needed and generally not recommended cosmetically.
Follow-up and reassurance

We review progress, adjust drop use, and remind that the underlying cause is temporary.

Prevention: how we minimise the risk next time

Preventing ptosis is a partnership between patient and injector. Our CLNQ protocol includes:

Injector-side techniques

Careful patient selection and assessment for pre-existing subtle ptosis or brow dependence.
Conservative starting doses, especially in first-timers or smaller foreheads; split dosing where appropriate.
Precise injection placement: avoiding low, deep, or medial points near the orbital rim; using the correct injection plane for the glabellar complex (corrugator/procerus).
Appropriate dilution and small aliquots per point to limit spread.

Patient aftercare

Keep upright for ~4 hours post-treatment.
Avoid rubbing, facials, helmets/tight caps, saunas/very hot yoga, or high-intensity exercise the same day.
Follow any bespoke advice your clinician gives you based on your anatomy and treatment plan.

With these measures, the chance of eyelid ptosis becomes very small.

When is it not Botox ptosis?

It’s important not to miss other causes of a drooping lid:

True neurogenic ptosis (e.g., third nerve palsy, Horner syndrome) typically has other neurological or pupil changes—urgent assessment needed.
Age-related aponeurotic ptosis can be unmasked after forehead lines are softened.
Dermatochalasis (excess upper lid skin) and brow ptosis can mimic lid droop.

If anything doesn’t fit the usual pattern after injections, we examine you promptly.

Evidence in brief

Mechanism: BoNT-A diffusion to the levator palpebrae superioris is the main cause; risk is higher with injections in mid-pupillary line regions of the glabella if placed too low/deep.
Apraclonidine: Traditional first-line symptomatic therapy; 1–2 drops t.i.d.; lifts 1–2 mm via Müller’s muscle contraction.
Oxymetazoline 0.1%: Randomised, double-masked trials show significant MRD1 and superior field improvement in acquired ptosis; widely adopted post-approval for toxin-related cases.
Brimonidine gel 0.33%: Case report indicates possible benefit applied to upper lid skin; more data needed.
Recent reviews: 2021–2025 literature summarises anatomy, risk factors, and modern management of BoNT-A–induced blepharoptosis.

What to expect at CLNQ (Botox Manchester)

Expert assessment: We rule out brow-only descent and screen for red flags.
Targeted relief: Where appropriate, we prescribe apraclonidine or oxymetazoline and show you how to use drops safely.
Follow-through: We check you within 1–2 weeks and adapt care if needed.
Plan for next time: We map your anatomy, adjust dose/siting, and record the plan to reduce risk in future sessions.

If you’re experiencing a droopy eyelid after Botox in Manchester or Cheshire, get in touch and we’ll see you promptly.

Patient tips: living with eyelid ptosis while it settles

Use prescribed drops as directed; don’t exceed frequency without advice.
Use artificial tears if you feel dryness (some adrenergic drops can dry the eye).
Drive only if your vision is clear; if the lid partly covers the pupil and you feel unsafe, avoid driving.
Slightly raise reading material or tilt your chin up to reduce strain if one lid is lower.
Keep to follow-up appointments—we can tweak your plan.

Frequently asked questions

1) Is a droopy eyelid after Botox permanent?

No. It’s temporary for the vast majority of patients. With or without drops, it usually improves over 2–8 weeks as nerve activity recovers.

2) How fast do the eye drops work?

Apraclonidine often acts within minutes and lasts 4–6 hours per dose; oxymetazoline has a sustained effect through the day with once-daily dosing in trials.

3) Are there side effects or people who shouldn’t use the drops?

Possible effects include eye redness, dryness, irritation, headache, or pupil changes. They may not be suitable if you have certain types of glaucoma, are on monoamine oxidase inhibitors, or have hypersensitivity. We screen for this during consultation.

4) Can extra Botox fix a droopy eyelid?

No. Additional toxin near the brow/lid risks worsening aperture. Management focuses on symptomatic drops and time.

5) Can makeup or taping help?

Makeup can disguise asymmetry; we generally avoid taping because of skin irritation and inconsistent results. Drops are more effective.

6) How do you prevent it happening again?

Accurate injection mapping, conservative dosing, avoiding low/deep points in the glabella, and good aftercare (upright, no rubbing/exercise the same day).

7) I’ve read about brimonidine gel—does it work?

One case report suggests 0.33% brimonidine gel applied to the upper lid skin helped lift the lid without ocular side effects. Evidence is limited; we can discuss off-label options if standard drops are unsuitable.

8) When should I worry?

If you develop double vision, severe headache, unequal pupils, or sudden vision loss, seek urgent care. Otherwise, book a review for tailored advice.

9) Does this mean Botox isn’t safe for me?

Eyelid ptosis is an uncommon and temporary side effect. With tailored techniques and aftercare, most patients continue treatment without recurrence.

10) Can I still book Botox in Manchester if I’ve had ptosis before?

Yes—simply choose an experienced doctor injector. At CLNQ we modify map/dose/planes to minimise risk, and we keep drops on hand if you need them.

Why choose CLNQ for Botox in Manchester?

Doctor-led clinic: You’re assessed by experienced medical professionals with deep knowledge of ocular and facial anatomy.
Safety-first protocols: Prevention-oriented dosing and placement, meticulous documentation, and clear aftercare.
Rapid support: Same-week reviews for post-treatment concerns and access to effective symptomatic therapies.
Personalised plans: Your face is unique; your plan should be too.

Ready to speak to our team? Contact CLNQ for an assessment and personalised plan for Botox Manchester and Cheshire patients.

References

Nestor MS, et al. Botulinum toxin–induced blepharoptosis: Anatomy, etiology, prevention, and treatment. 2021.
King M. Management of Ptosis. 2016. Guidance including apraclonidine dosing.
Bacharach J, et al. Acquired blepharoptosis: prevalence, diagnosis and treatment. 2021.
Slonim CB, et al. Association of oxymetazoline 0.1% with eyelid elevation & visual field. 2020.
Alotaibi GF, et al. Eyelid ptosis after botulinum toxin treated with topical brimonidine gel. 2022.
Witmanowski H, et al. The whole truth about botulinum toxin – a review. 2019 (mechanism and risk zones).
Johnson AJ, et al. Office-based facial plastics procedures: neuromodulators. 2023 (practical pearls).

Final word

A droopy eyelid after Botox is understandably frustrating but almost always temporary and treatable. The combination of skilled technique, sensible aftercare, and access to effective drops gets most patients looking and feeling themselves again quickly. If you’re worried after treatment—or want an expert second opinion—book a review at CLNQ (Botox Manchester) and we’ll help you put it right.

Glutathione The Secret of Skin Health

Glowing, youthful skin is often seen as the hallmark of health and vitality. While skincare routines and aesthetic treatments play a big role, true skin wellness starts at the cellular level. One molecule that’s gained global recognition for its remarkable benefits is glutathione — often called “the master antioxidant.”

At CLNQ, our philosophy focuses on helping patients achieve skin health from within. We will explore how glutathione works, its effects on the skin, clinical evidence supporting its use, and how you can safely incorporate it into your skincare and wellness routine.

What Is Glutathione?

Glutathione is a small but powerful tripeptide made from three amino acids: cysteine, glycine, and glutamate. It is produced naturally in the liver and found in nearly every cell in the body.

This molecule plays several vital roles:

Neutralising free radicals: Glutathione acts as a potent antioxidant, protecting cells from oxidative stress caused by pollution, UV rays, and toxins.
Detoxifying the body: It binds to harmful substances, helping the liver remove them efficiently.
Supporting immunity: Glutathione helps regulate immune responses and defends against infections.
Regenerating other antioxidants: It reactivates vitamins C and E, amplifying your body’s natural antioxidant defences.

As we age, glutathione levels naturally decline. Factors such as stress, poor diet, illness, and sun exposure accelerate this depletion — leaving skin looking dull, uneven, or prematurely aged.

How Does Glutathione Affect the Skin?

Glutathione’s benefits extend beyond general health; it directly impacts the skin’s brightness, tone, and resilience.

1. Skin Brightening and Pigmentation Control

Glutathione helps reduce melanin production by inhibiting the enzyme tyrosinase, which is responsible for synthesising pigment. It also shifts the balance from eumelanin (dark pigment) to pheomelanin (lighter pigment), leading to a naturally brighter, more even skin tone.

This is why glutathione is often used to improve:

Uneven skin tone
Sun spots and pigmentation
Melasma and post-inflammatory hyperpigmentation

2. Powerful Antioxidant Protection

Every day, your skin is bombarded by oxidative stress — from UV exposure, pollution, and inflammation. Glutathione acts as a frontline defender, neutralising reactive oxygen species (ROS) that damage collagen, elastin, and DNA.

By protecting the skin barrier, glutathione helps prevent:

Premature ageing
Fine lines and wrinkles
Sun-induced pigmentation and rough texture

3. Anti-Ageing and Collagen Support

Healthy collagen production depends on a stable cellular environment. By reducing oxidative damage, glutathione supports fibroblast activity — the cells responsible for producing collagen and elastin.

The result? Skin that looks firmer, smoother, and more youthful.

4. Detoxification and Skin Clarity

Because glutathione helps the liver eliminate toxins, it indirectly promotes clearer skin. Many people report improvements in acne-prone or congested complexions after increasing glutathione intake.

What Does Science Say About Glutathione for Skin?

Over the past decade, several clinical studies have investigated the link between glutathione and skin appearance.

A 12-week clinical trial (Published in Clinical, Cosmetic and Investigational Dermatology, 2017) found that oral glutathione (250 mg daily) significantly reduced melanin index and improved skin tone and elasticity in women aged 30–50. Glutathione for skin lightening shows growing evidence supporting its use.
Topical formulations containing oxidised glutathione (GSSG) demonstrated noticeable improvements in hydration, smoothness, and wrinkle reduction after 10 weeks.
Combination therapies using L-cysteine and glutathione showed enhanced brightening effects, supporting their use in skin rejuvenation programmes.

While results vary depending on dosage and duration, the evidence consistently shows that glutathione supports a brighter, clearer, and more youthful complexion when used regularly.

How Can You Boost Glutathione Levels?

There are multiple ways to increase glutathione in the body. At CLNQ, we tailor treatment approaches to each individual’s goals, health status, and lifestyle.

1. Dietary Sources

You can support natural glutathione production through nutrition:

Sulphur-rich foods: Garlic, onions, and cruciferous vegetables (broccoli, kale, cabbage) boost cysteine levels, a key glutathione component.
Antioxidant foods: Citrus fruits, berries, and avocados support regeneration of glutathione.
Lean proteins: Poultry, fish, and eggs provide amino acids needed for synthesis.

2. Oral Supplements

Glutathione supplements are widely available in capsules, tablets, or sublingual forms. Clinical research suggests that 250–500 mg per day may help improve skin tone and oxidative balance.

At CLNQ, we recommend pharmaceutical-grade formulations to ensure bioavailability and safety.

3. IV Glutathione Therapy

Intravenous (IV) infusions deliver glutathione directly into the bloodstream for maximum absorption. This approach is often combined with vitamin C and B-complex infusions to enhance antioxidant synergy.

Benefits may include:

Brighter, more radiant complexion
Improved recovery after aesthetic procedures
Enhanced detoxification and energy levels

While IV therapy can be highly effective, it must always be administered under medical supervision. At CLNQ, our clinicians ensure treatments are evidence-based, safe, and tailored to your needs.

4. Topical Glutathione Formulas

Modern skincare now includes topical products infused with glutathione. These can help reduce oxidative damage and pigmentation locally when combined with vitamin C, niacinamide, or retinol. A study has shown benefits for combination treatments for dark circles.

Who Can Benefit from Glutathione?

The therapy may be suitable for:

Individuals with pigmentation or uneven skin tone
Those seeking anti-ageing support or protection from photoageing
People exposed to urban pollution or chronic stress
Patients recovering from aesthetic or surgical procedures
Those with oxidative stress-related skin conditions, such as dullness or inflammation

However, results depend on baseline glutathione levels, lifestyle, and consistency of treatment. Our team at CLNQ will discuss the benefits of glutathione.

Is Glutathione Safe?

When used appropriately, glutathione is generally safe and well-tolerated.

Clinical studies report minimal side effects with oral and topical formulations. However, the intravenous route should only be used under medical supervision, as inappropriate administration can cause rare but serious complications.

At CLNQ, we ensure each patient undergoes a detailed consultation before any IV or injectable therapy. We assess individual risk factors, monitor outcomes, and use medical-grade ingredients sourced from reputable UK pharmacies.

Glutathione at CLNQ

At CLNQ Manchester and Cheshire, we offer comprehensive wellness and skin health programmes that include glutathione therapy as part of a holistic approach.

Our treatments are often combined with:

Vitamin C infusions for antioxidant synergy
NAD+ therapy to enhance energy and repair
Red light therapy (Photobiomodulation) for skin rejuvenation
Morpheus8 or laser resurfacing for collagen stimulation

By integrating internal and external treatments, we help our patients achieve long-lasting, natural-looking results that enhance both skin appearance and overall wellbeing.

Key Benefits of Glutathione for Skin Health

1. Brightens and evens out skin tone

By reducing melanin production, glutathione helps achieve a naturally luminous complexion.

2. Reduces signs of ageing

It combats oxidative stress, minimising fine lines, wrinkles, and dullness.

3. Detoxifies the body

Supports liver function and flushes out harmful substances that affect skin clarity.

4. Improves skin texture

Hydration and elasticity are enhanced, giving skin a smoother feel.

5. Enhances overall wellness

As a systemic antioxidant, glutathione supports immune health and cellular repair — ensuring your skin looks as good as you feel.

The CLNQ Approach to Skin Longevity

At CLNQ, we believe true beauty begins with cellular balance. Our longevity and skin programmes combine advanced medical science with aesthetic expertise. Glutathione plays a central role in maintaining this balance by promoting healthy, radiant, and resilient skin.

Our clinicians assess your lifestyle, skin type, and goals before designing a bespoke treatment plan, which may include:

Blood testing for antioxidant and nutrient levels
Tailored infusion protocols
Combination therapy with red light or NAD+
Personalised skincare and supplementation advice

This holistic method helps sustain results long term while improving how you feel from within.

Conclusion

Glutathione is more than a beauty trend — it’s a scientifically backed molecule that protects, renews, and brightens your skin from within. By fighting oxidative stress, supporting collagen production, and regulating pigmentation, glutathione can transform skin health when used as part of a comprehensive wellness programme.

At CLNQ, our expert-led treatments combine cutting-edge medical science with aesthetic artistry. Whether you’re looking to restore radiance, improve tone, or support recovery after a procedure, glutathione therapy can be a powerful ally on your journey to glowing, youthful skin.

FAQs About Glutathione for Skin Health

1. How long does it take to see results from glutathione?

Most people notice brighter, more even skin within 4–8 weeks, especially when treatment is combined with a good skincare routine and antioxidant-rich diet.

2. Is oral glutathione effective?

Yes. Clinical studies show that oral glutathione can reduce pigmentation and improve skin tone when taken consistently for 2–3 months.

3. Can glutathione help with acne?

Indirectly, yes. By reducing oxidative stress and supporting detoxification, glutathione can improve overall skin clarity and reduce post-acne pigmentation.

4. Are IV glutathione treatments safe?

When performed by trained medical professionals, IV therapy is generally safe. At CLNQ, all treatments are doctor-led and customised to individual needs.

5. Does glutathione permanently lighten the skin?

Results may fade if supplementation or treatment stops. Continuous maintenance and sun protection are essential to preserve the effects.

Red Light Therapy after Surgery

Red light therapy—also called photobiomodulation (PBM) or low-level light therapy (LLLT)—uses specific wavelengths of red and near-infrared (NIR) light to support tissue repair, reduce inflammation and swelling, and improve the appearance and feel of scars. At CLNQ Manchester we use medical-grade LED devices in a controlled protocol designed for post-operative recovery after procedures such as breast surgery, tummy tuck, liposuction, face lift surgery and skin lesion removal.

What is red light therapy?

Red light therapy is a non-invasive treatment delivering low-energy red (typically 630–660 nm) and near-infrared (typically 800–850 nm) light to tissues. These wavelengths penetrate the skin and are absorbed by chromophores (notably cytochrome-c oxidase within mitochondria). This interaction can increase cellular ATP production, modulate reactive oxygen species and nitric oxide, and trigger downstream anti-inflammatory and pro-healing effects. Evidence syntheses describe these molecular and cellular mechanisms across skin and musculoskeletal tissues.

In practical terms, patients experience comfortable, warm light exposure for a set time (often 10–20 minutes per region). There is no downtime, and it can be started early in the post-operative pathway if your surgeon agrees and wounds are appropriately protected.

Why consider red light therapy after surgery?

1) Supports wound healing

Controlled clinical and translational studies suggest PBM can accelerate the early stages of wound repair, improving cellular migration and collagen organisation. Recent work across cutaneous models and clinical settings points to modulation of inflammation and improved antioxidant activity that together may speed epithelial recovery.

2) May reduce post-operative pain and swelling

A systematic review of PBM in surgical recovery has reported reductions in post-operative pain and, in several procedures, lower analgesic use—which can be beneficial when trying to limit opioid-related side effects. Dental and oral-surgery literature (often a useful surrogate for soft-tissue healing) also shows improvements in pain, swelling (oedema) and trismus after third-molar surgery.

3) Improves scar quality and pliability

A phase II split-face clinical trial using LED red light in the early post-operative period on facial skin found improvements in scar pliability and cosmesis at specific fluences, with a favourable safety profile. This aligns with the proposed antifibrotic effects of PBM on dermal remodelling.

4) Safe, non-invasive, no downtime

Unlike lasers used for skin resurfacing, medical-grade LED PBM delivers non-thermal energy at sub-ablative levels, making it well-tolerated and easy to integrate between dressings, follow-ups and lymphatic drainage sessions when indicated. Authoritative hospital resources also recognise PBM’s broad use in scar management and inflammatory skin concerns.

How PBM works

Energy boost: Red/NIR photons interact with mitochondria, nudging cells to make a little more ATP—useful energy for repair.
Inflammation modulation: PBM tends to down-regulate pro-inflammatory cytokines and up-regulate signals associated with resolution and tissue rebuilding—patients often notice less puffiness.
Microcirculation: Improved blood flow and lymphatic drainage can help shift fluid and by-products of inflammation.
Collagen remodelling: Early scar care aims for orderly collagen deposition; PBM appears to encourage balanced remodelling, supporting softer, more pliable scars over time.

Conditions and surgeries that may benefit

Breast surgery (augmentation, reduction, mastopexy): can help with discomfort, swelling and scar care.
Abdominoplasty (tummy tuck) and liposuction: helpful adjunct to reduce oedema and support even tissue recovery.
Facial surgery (blepharoplasty, facelift, rhinoplasty): early, careful use to improve bruising and swelling, and longer-term scar appearance.
Minor skin surgery (mole/cyst excision): supports neat scars when combined with meticulous suture technique and silicone therapy.
Oral and dental procedures: literature shows benefits in pain, swelling and function after extractions.

PBM is adjunctive—it complements, but does not replace, surgical skill, sterile technique, wound care, activity modification, good nutrition and follow-up.

What happens at CLNQ Manchester?

Consultation & timing

We review your operation type, healing stage, dressings and any contraindications. PBM is usually introduced once wounds are secure or protected (sometimes same-week after surgery if appropriate).
Device & dosing

We use medical-grade LED panels delivering red and NIR wavelengths. Typical fluence (energy per area) and session length are protocolised to your procedure and skin type. Evidence from dose-ranging studies informs our conservative starting parameters and progressive adjustments.
Session plan

Acute phase (week 1–2): 2–3 sessions/week focusing on oedema and discomfort.
Subacute phase (weeks 3–6): 1–2 sessions/week supporting remodelling.
Scar maturation (weeks 6–12+): targeted scar modules (PBM plus silicone/taping/massage) depending on risk factors (site tension, Fitzpatrick type, history of hypertrophy).

Your plan is always tailored following review by our surgical and skin teams.

Safety, side effects and who should avoid it

PBM has a strong safety profile when delivered with correct eye protection and dosing. Most patients experience no side effects beyond a gentle warmth. Rarely, there may be transient redness or a mild headache. The primary safety principle is ocular protection—we always shield the eyes and never shine light directly into them. Reviews and safety notes emphasise eyewear and avoidance of direct ocular exposure.

Relative/absolute cautions include:

Over known or suspected malignancy (avoid treating directly over tumour sites).
Pregnancy (avoid direct treatment over the abdomen).
Photosensitising medicines/conditions (e.g., certain antibiotics, isotretinoin, lupus): we will screen and adapt.
Active infection at the site (treat the infection first).

As with all medical treatments, we individualise decisions based on your history and surgeon’s guidance.

Evidence

Post-surgical pain & recovery: A review of studies across different surgeries (including breast augmentation, hernia, tonsillectomy and orthopaedics) reported reduced pain and sometimes reduced analgesic consumption with PBM. Effects vary by protocol and timing.
Scars: A phase II randomised, split-face trial of red LED after facial surgery suggested improved scar pliability and appearance at certain doses, with good safety.
Oral surgery meta-analysis: PBM can reduce pain, swelling and trismus after third-molar extraction—findings that echo PBM’s broader wound modulation.
Mechanisms: Contemporary reviews outline mitochondrial and cytokine-level changes underpinning inflammation resolution and tissue remodelling.

Limitations: Studies can differ in wavelengths, fluence, treatment timing and outcome measures, so protocols are not one-size-fits-all. That’s why we employ carefully titrated, evidence-informed dosing rather than consumer-device assumptions.

Red light therapy vs home devices

Home devices vary widely in power density, beam uniformity and safety features. Many are under-powered, leading to longer treatment times or inadequate dosing; others lack consistent eye protection guidance. Medical-grade clinic systems deliver reliable irradiance across a larger field with professional oversight, allowing protocolised, repeatable outcomes—especially important after surgery where sterility and scar management strategies must be synchronised.

Your recovery pathway at CLNQ Manchester

Day 0–7: Surgical aftercare with wound checks; introduce PBM when appropriate. Combine with elevation, compression (when indicated) and prescribed analgesia.
Weeks 2–6: PBM to aid swelling control and comfort; begin scar routine (silicone gel/tape, SPF 50, gentle massage).
Weeks 6–12+: Targeted PBM for hypertrophic scar risk areas; consider adjuncts such as vascular laser for redness or microneedling/laser resurfacing at the correct stage if needed.

Goal: A smoother, more comfortable recovery with better-quality scars and faster return to daily life.

Who is an ideal candidate?

You’ve had (or are planning) cosmetic or reconstructive surgery and want a structured recovery plan.
You prefer non-pharmacological adjuncts to help manage swelling and discomfort.
You’re keen to invest in scar care strategies that support long-term aesthetics.

We will screen your medical history and tailor the protocol.

Frequently asked questions (FAQs)

Is red light therapy painful?

No. You’ll feel gentle warmth but no burning. Sessions are short and you can return to normal activities immediately.

How soon after surgery can I start?

Often within the first week, depending on your procedure, dressings and wound status. We’ll confirm safety at your review.

How many sessions will I need?

Most post-operative plans include 6–12 sessions across the first 6–12 weeks, adjusted for your healing and scar risk.

Will it help my scar?

Evidence suggests PBM can improve scar pliability and appearance when used as part of a structured scar plan (silicone, massage, sun protection). Results vary.

Is it safe around the eyes?

We always use proper eye protection and never shine light directly into the eye. Safety guidance stresses ocular protection.

Can I use my home device instead?

Some patients complement clinic sessions with home use, but dosing is often inconsistent. We can advise if you already own a device.

Is it suitable if I have a history of keloids?

You may still benefit, but you’ll need a custom scar plan and close follow-up; we may add silicone, pressure, or consider other modalities if needed.

Any reasons not to have PBM?

We avoid treating over active cancer, over the pregnant abdomen, over active infection, and we’ll review any photosensitising medications.

Red Light Therapy Manchester – Why choose CLNQ?

Consultant-led care: Protocols designed by surgeons and medical skin specialists experienced in post-operative recovery.
Medical-grade technology: Consistent irradiance and field coverage for predictable dosing.
Integrated scar programme: PBM sits alongside silicone therapy, vascular laser, microneedling or fractional laser (when indicated) for comprehensive results.
City-centre access: Convenient Manchester location with flexible appointments to fit your follow-ups.
Holistic recovery: Advice on sleep, nutrition, compression, lymphatic drainage and activity pacing to support healing.

How to book

If you’re searching for “red light therapy Manchester” or planning surgery with us, our team can incorporate PBM into your pre- and post-op plan. Contact CLNQ to arrange an assessment and build your personalised recovery schedule.

Key references

Kurtti A, Nguyen JK, et al. Light-emitting diode red light for reduction of post-surgical scarring: phase II trial demonstrating safety and improved scar measures at certain fluences. J Biophotonics.
Ezzati K, et al. Effects of photobiomodulation therapy on post-surgical pain: review reporting reduced pain and analgesic use in several surgeries. Lasers Med Sci (PMC).
Giansiracusa A, et al. PBM after third-molar extraction: systematic review/meta-analysis indicating reductions in complications. J Clin Med.
Da Silva TG, et al. Photobiomodulation at molecular, cellular and systemic levels: review of mechanisms relevant to wound healing. Life Sci.
Cleveland Clinic. Red Light Therapy overview: general description and use cases.

Rosacea Laser Treatment

Persistent flushing, visible blood vessels (telangiectasia), and a red, irritated complexion can undermine confidence and quality of life. At CLNQ Manchester, we specialise in medically supervised rosacea laser treatment that combines science, safety and aesthetic finesse. We explain the condition, how lasers help, evidence from literature, what to expect, safety, package options, and answers common questions.

Understanding Rosacea: The Basics & Why Lasers Help

What is Rosacea?

Rosacea is a chronic inflammatory skin disorder, predominantly affecting the central face (cheeks, nose, chin, forehead). Its hallmark features include:

Persistent erythema (background redness), often with transient flushing episodes
Telangiectasia / fine visible blood vessels (thread veins)
In some types, papules and pustules (similar to acne)
Occasionally skin thickening (e.g. rhinophyma) and ocular involvement (eye irritation, redness)

Importantly, rosacea is not just cosmetic: vascular reactivity, inflammation and barrier dysfunction play key roles. Sharma et al. in a recent comprehensive review emphasise that persistent erythema and telangiectasia are core features best addressed by vascular/light-based therapies in appropriate patients.

Triggers (heat, sun, spicy foods, alcohol, stress) aggravate vasodilation, but modifying those alone is seldom sufficient when vessel networks are established.

Why Laser & Light-Based Therapy?

Lasers and other light-based modalities act by selectively heating haemoglobin-bearing vessels. The energy converts to heat, causing coagulation and collapse of superficial capillaries, which are then resorbed by the body. Over repeated sessions, this reduces visible redness and vessel conspicuity.

In a recent meta-analysis, Zhai et al. compared intense pulsed light (IPL) and pulsed-dye laser (PDL) in the management of rosacea. They found that while PDL and IPL had similar outcomes for ≥50% clearance, IPL showed a statistically significant advantage for >75% clearance, albeit with somewhat higher discomfort. Their conclusion: both modalities are effective, though patient tolerance, vessel type, skin type and downtime preferences should guide choice.

Another systematic review/meta-analysis (Husein-ElAhmed et al.) evaluated a broader array of light-based therapies (including PDL, Nd:YAG, IPL). That work found no major differences in efficacy across modalities for erythema, telangiectasia, physician/patient satisfaction — although the quality of evidence remains low-to-moderate. Among available options, PDL has the strongest body of evidence. At our laser clinic Manchester we have the VBeam PDL laser.

Thus, in clinical practice a bespoke approach is essential: choosing device, settings and cooling strategies to suit your vessel pattern, skin type and tolerance.

Choosing the Right Technology at CLNQ

At CLNQ we offer multiple vascular/light-based platforms so we can tailor protocols:

Pulsed-Dye Laser (PDL / VBeam): excellent for diffuse background erythema and fine vessels. Shorter wavelengths target haemoglobin very selectively, with well-established safety in the literature.
Nd:YAG (1064 nm, sometimes 532 nm adjunctively): deeper penetration allows treatment of thicker and deeper vessels (especially around the nose or bluish veins). In darker skin types, longer wavelengths (1064 nm) reduce pigment risk when correctly applied.

Your consultation at CLNQ includes vessel mapping (colour, depth, calibre), skin type (Fitzpatrick scale), risk factors (pigmentation, previous treatments), and comfort thresholds. Based on this, we propose the optimal device or combination.

Who is a Suitable Candidate?

You may be a strong candidate for rosacea laser treatment if:

You have persistent facial redness or flushing not fully controlled by topicals or lifestyle changes
You see thread veins or telangiectasia in cheek, nose or chin zones
You do not have active infection, severe sunburn, uncontrolled skin disease in the treatment area, or diseases that increase light sensitivity
You are not heavily tanned or using strong photosensitising medications (or can pause them)
You understand rosacea is chronic and may require maintenance sessions

Patients with papulopustular rosacea may still benefit from laser for vascular signs, but medical therapy is often needed in parallel. The Sharma et al. review underlines that multimodal therapy (topicals, systemic, lasers) is often the most pragmatic route.

What to Expect: From First Visit to Final Result

Consultation & Mapping

Detailed history (rosacea onset, triggers, prior therapies)
Skin assessment: thickness, pigmentation, sensitivity
Vessels mapping: superficial vs deeper; red vs bluish
Patch test (small area) to assess skin reaction and ideal settings
Develop a custom treatment plan (number of sessions, device(s), downtime expectations)

Treatment Day

Clean skin (no makeup)
Protective eyewear
Cooling (air, contact, gel) is used before, during and after pulses
Laser pulses delivered: you’ll feel quick, warm “snaps” or pinprick sensations
For PDL, you may see immediate vessel darkening or purpura (bruising) in more aggressive settings; subpurpuric modes reduce that risk
Cooling and soothing post-treatment

Typical session: 15–30 minutes (depending on area). You’ll be monitored during the process for skin reaction.

Aftercare & Recovery

Mild redness, swelling for 24–72 hours
Possible purpura/bruising especially when aggressive PDL settings used (can last 5–7 days)
Use soothing moisturisers, avoid picking or exfoliation
Avoid heat exposures, exercise, alcohol, saunas, hot showers immediately after (24–48 hours)
Strict use of broad-spectrum SPF 50+ daily
Return to gentle skincare; more active agents resumed per clinician advice
Follow-up 3–6 weeks later for next session

Treatment Course & Maintenance

Most patients require 3–4 sessions, spaced 3–6 weeks apart
Results develop gradually: vessels are resorbed over weeks
Maintenance treatments 6–12 monthly help reduce relapse
Many patients combine laser with trigger control, SPF, topical/systemic therapy for more durable results (a multimodal approach endorsed in literature)

Evidence & Safety: What the Literature Shows

Efficacy Comparisons

Zhai et al. (2024, meta-analysis, n=141 participants) compared PDL vs IPL in rosacea. The authors found no significant difference in achieving ≥50% clearance, but IPL had an edge in >75% clearance, albeit with more discomfort.
Husein-ElAhmed et al. (2022) broadly compared light-based therapies. They observed similar performance across PDL, Nd:YAG and IPL in erythema and telangiectasia outcomes. The evidence was described as low-to-moderate quality, so clinical judgment remains key.
Sharma et al. (2022) in the rosacea management review emphasize that lasers and light-based therapies are best reserved for the erythematotelangiectatic subtype (i.e. those dominated by redness and vessels), often as adjuncts to medical therapy.

Thus, your treatment plan should align evidence with your specific skin and vessel profile, rather than a one-size-fits-all laser.

Safety Considerations

Lasers are generally safe when used by trained clinicians with appropriate cooling, patch testing and conservative settings. Potential side effects include:

Transient erythema, swelling
Bruising (purpura) — more likely with aggressive PDL
Transient hyperpigmentation or hypopigmentation (especially in higher Fitzpatrick types)
Blistering, crusting (rare)
Scarring (very rare, if misused)

By selecting proper settings, cooling, and respecting skin type, the risk is minimal. Our protocols emphasise conservative approaches on darker phototypes and patch testing.

Why CLNQ Manchester Laser Clinic Stands Out

Medical-led environment with safety protocols and clinical oversight
Access to multiple vascular/light devices, enabling individualised protocols
In-depth vessel mapping and patch testing, reducing surprises and optimising outcomes
Holistic rosacea plans (laser + trigger coaching + skincare + medical therapy)
Clinic in Manchester city centre (easy for patients in Greater Manchester, Salford, Didsbury, Altrincham)
Convenient appointment times including evenings & Saturdays
Transparent consultation process and pricing packages

Pricing & Packages

Because rosacea laser pricing depends on factors such as the size of the area, vessel density and device used, we prefer to provide individualised quotations. However as a guideline:

Many patients commit to a 3–4 session course
Maintenance packages often priced more affordably
You receive a full cost breakdown at consultation, so there are no hidden fees
You will need an initial consultation with our skin doctors which is £100

Preparation & Aftercare Guidance

Pre-Treatment Checklist

Avoid sun and self-tanning for 2–4 weeks
Discontinue photosensitising topicals (e.g. strong acids, retinoids) as advised
Avoid alcohol, saunas, strenuous workouts 24–48 hours before
Clean skin on arrival (no make-up)
Disclose cold sore history — prophylactic antivirals can be used if needed

Post-Treatment Care

Cool the skin gently (ice packs wrapped in cloth) first 24 hours
Use bland, fragrance-free moisturiser
Apply broad-spectrum SPF 50+ every morning
Avoid heat, alcohol, intense exercise, saunas for at least 48 hours
Let any darkening or flaking resolve naturally — no picking
Resume actives (e.g. gentle acids, retinoids) only after clearance and per our direction
Attend all follow-up laser sessions in your plan

FAQs — Rosacea Laser Treatment Manchester

Is laser effective for rosacea?

Yes. Lasers and light-based therapies are among the most powerful tools to reduce persistent erythema and visible vessels, particularly for the erythematotelangiectatic subtype of rosacea.

Which laser or light is best for my skin?

The PDL or VBeam has often been used as the gold standard laser for vascular lesions.

How many sessions will I need?

Most patients undertake 3–4 sessions, 3–6 weeks apart. Maintenance sessions every 6–12 months help sustain results.

Does it hurt?

You’ll feel brief, warm “pulse” sensations (often like a rubber-band snap). Cooling helps reduce discomfort. In some comparative analyses, PDL was found to have lower pain scores than IPL.

What is the downtime?

Redness and swelling are typical for 1–3 days. Purpura (bruising) may occur, especially with more aggressive PDL settings, and can last up to one week.

Will redness come back?

Yes, rosacea is a chronic condition. New vessels may form over time. Maintaining SPF, managing triggers, and occasional touch-up treatments help maintain results.

Can people with darker skin receive rosacea laser?

Yes—but with more caution. Using longer wavelengths (e.g. Nd:YAG 1064 nm), patch testing, lower energy and gradual escalation reduces pigment risk.

Can laser treat papulopustular aspects of rosacea?

Not directly. The inflammatory papules require medical therapy (topicals, antibiotics). Laser is best used to treat the vascular component. A combined approach is often optimal (as highlighted in Sharma et al.).

Is laser safe during pregnancy or with certain medications?

Generally avoided during pregnancy. Some medications (photosensitising drugs, isotretinoin) may need pausing before treatment; this is reviewed during consultation.

How much does it cost in Manchester?

Our course pricing is customised by area and vessel complexity. At consultation, you’ll be given a full breakdown — no surprises.

Summary at a Glance

Goal: Reduce background redness and visible vessels in rosacea
Best suited: Patients with erythematotelangiectatic rosacea or mixed types where vascular features persist
Core devices: PDL/VBeam-type, Nd:YAG (1064 nm), IPL
Evidence: Meta-analyses show broadly comparable efficacy across modalities; PDL has the strongest historical evidence base
Plan: 3–4 sessions spaced 3–6 weeks + maintenance
Downtime: Mild swelling/redness; possible bruising with aggressive settings
Safety: Low when managed by experienced clinicians
Complementary strategies: SPF, trigger control, medical therapy
Locations: CLNQ Manchester laser clinic
Booking: Enquire to schedule a detailed consultation and tailored programme

Mitochondrial Function and Longevity

Mitochondria are tiny powerhouses within almost every cell in our body. They generate the energy we need, help regulate metabolism, assist in repairing damage, and even play roles in cell death. Because they are central to so many cellular processes, how well mitochondria function is strongly linked to aging, healthspan, and lifespan. In this article, we explore how mitochondrial function changes with age; what biological mechanisms connect mitochondrial health to longevity; and what current research suggests we can do to preserve mitochondrial health and potentially slow or even reverse aspects of aging.

What are Mitochondria and Why They Matter

Structure and basic role

Mitochondria are organelles with a double membrane. Inside, a sequence of protein complexes (the electron transport chain) uses nutrients (carbohydrates, fats, proteins) to produce adenosine triphosphate (ATP), the cell’s energy currency. They also have their own DNA (mtDNA), which encodes key components of the respiratory chain. In addition, mitochondria help regulate calcium, generate reactive oxygen species (ROS), participate in programmed cell death (apoptosis), and have roles in metabolism and hormonal signalling.
Dynamic behaviour

They constantly undergo fission (splitting), fusion (joining), biogenesis (making new mitochondria), and mitophagy (removing damaged ones). These processes maintain a healthy mitochondrial network. When they become unbalanced, mitochondrial dysfunction arises.

How Mitochondrial Function Declines with Age

Research over the past decades has shown that mitochondrial function tends to worsen as we grow older. Key changes include:

Reduced ATP production

Efficiency of the electron transport chain decreases; proton leaks increase; fewer healthy mitochondria. Result: cells have less energy.
Increased reactive oxygen species (ROS)

ROS are by-products of energy production. At moderate levels they act in signalling; but high levels cause oxidative damage to proteins, lipids, DNA (including mtDNA), contributing to aging.
Accumulation of mutations in mitochondrial DNA

mtDNA is prone to damage because of proximity to ROS, lack of some DNA repair mechanisms. Mutations accumulate over time. Some experimental models (e.g. “mutator” mice/flies) show that high mutation burden coincides with premature aging.
Impaired quality control

Reduced mitophagy (removal of dysfunctional mitochondria), reduced mitochondrial biogenesis, and imbalance in fission/fusion. Mitochondrial dynamics go awry.
Altered metabolic signalling

Nutrient-sensing pathways (e.g. insulin/IGF-1, TOR (Target of Rapamycin), AMPK, sirtuins) that normally help adapt the cell’s metabolism become less efficient or dysregulated. This leads to mitochondrial inefficiency.
Inflammation and cellular senescence

Chronic low-grade inflammation (“inflammaging”) increases, partly due to mitochondrial dysfunction. Senescent cells (cells that no longer divide) often have dysfunctional mitochondria which produce more ROS and inflammatory signals.

Mechanisms Linking Mitochondrial Health to Longevity

How exactly does mitochondrial decline affect lifespan? Here are key mechanisms, drawn from recent literature:

Oxidative Stress and Free Radical Theory Revisited

The old “free radical theory of aging” (ROS cause damage → aging) has been refined. We now understand that ROS also serve essential signalling roles, but that excess or poorly regulated ROS contribute to damage. Some antioxidant strategies have failed in trials, possibly because they blunt necessary ROS signalling or because downstream damage has already become too great.
Nutrient-Sensing Pathways (IIS, TOR, AMPK, Sirtuins)

Calorie or nutrient restriction, or lower signalling through insulin/IGF-1 / TOR pathways, is one of the most robust ways shown in many species to extend lifespan. These interventions often improve mitochondrial biogenesis, reduce ROS, improve autophagy/mitophagy. For example, Bratic et al. (2013) described how mitochondrial metabolism mediates longevity effects of dietary restriction.
Quality Control Mechanisms: Mitophagy, Proteostasis, UPR^mt

Cells have mechanisms to remove or repair misfolded mitochondrial proteins, damaged mitochondrial membranes, and dysfunctional mitochondria. The mitochondrial unfolded protein response (UPR^mt) is activated when mitochondria are stressed; mitophagy selectively removes damaged mitochondria. Proper function of these maintenance pathways correlates with slower aging.
Mitochondrial Dynamics: Fission and Fusion

The balance of fusion and fission is essential for mitochondrial health. Fusion helps dissipate damage by mixing mitochondrial contents; fission helps isolate damaged parts for removal. With ageing, this balance is disrupted, leading to fragmented mitochondria, less efficient energy production, more ROS.
Communication and Signalling Role

Beyond energy production, mitochondria are signalling hubs. They influence apoptosis, immune signalling, hormone regulation, and cellular responses to stress. Their dysfunction can dysregulate these processes, contributing to age-related diseases (e.g. cardiovascular disease, neurodegeneration, metabolic disorders).
Lipid Composition of Mitochondrial Membranes

The types of fats in mitochondrial membranes affect how susceptible those membranes are to peroxidation (damage by ROS). Species or individuals with lower unsaturation (fewer double bonds in phospholipids) tend to have mitochondria that resist oxidative damage better. This is one possible factor correlating with longer lifespan.

Recent Advances & Emerging Insights

Recent research adds new angles:

Mitochondrial dysfunction as a hallmark of ageing

In the updated hallmarks of ageing, mitochondrial dysfunction is consistently included. The emerging consensus is that it’s both a cause and consequence of aging.
Metabolite signalling and mitochondrial stress responses

Mitochondria produce metabolites that influence nuclear gene expression, immune responses, senescence. The mitochondrial integrated stress response (mito-ISR) is being investigated as a way that cells react to mitochondrial dysfunction and perhaps signal for repair.
Mitochondrial transfer and intercellular communication

New studies suggest mitochondria may be transferred between cells under certain conditions, potentially helping rescue damaged cells. Though still experimental, this raises therapeutic possibilities. The “Mitochondria makeover” article (2023-24) discusses this.
Organ-specific mitochondrial decline

Different organs (e.g. brain, heart, muscle) show varying rates and types of mitochondrial dysfunction with age. Therapies may need to be targeted.
Nutrition, diet, and mitochondrial health

Diets known to promote longevity (e.g. Mediterranean diet, intermittent fasting) appear to act in part by maintaining mitochondrial function, reducing inflammation, improving mitochondrial efficiency.

What We Can Do to Support Mitochondrial Longevity

While many mechanisms remain under investigation, several interventions have shown promise in improving mitochondrial function and possibly extending healthy lifespan. Some are already practical; others are experimental.

Intervention	What it does for mitochondria	Evidence / potential
Dietary restriction / caloric/nutrient restriction	Reduces metabolic load, increases mitochondrial biogenesis, boosts autophagy, lowers ROS production	Strong evidence across many species; human trials show benefits for metabolic health, biomarkers of aging.
Intermittent fasting / time-restricted feeding	Periods of fasting stimulate mitochondrial turnover, improve stress resistance	Growing evidence in animal models; human studies still limited but promising.
Exercise	Increases mitochondrial biogenesis in muscle, improves fission/fusion dynamics, enhances removal of damaged mitochondria	Well-established; regular aerobic and resistance exercise are among the best interventions. (Although many studies are smaller scale; tissue-specific effects vary.)
Maintaining favourable macronutrient profile	Reducing excessive simple sugars, optimizing fats (especially reducing overly oxidisable lipids), ensuring adequate micronutrients (e.g. those involved in mitochondrial enzymes)	Diets like Mediterranean show benefit; excess saturated fats or omega-6 rich lipids may harm membrane composition.
Supplements / pharmacological agents	Agents such as NAD+ precursors, sirtuin activators, AMPK activators, compounds that mimic caloric restriction (e.g. metformin, rapamycin)	Early-stage human studies; animal data quite strong. Need careful dosing and risk-benefit evaluation.
Mitophagy enhancement / quality control enhancement	Promoting removal of damaged mitochondria; enhancing mitochondrial repair and protein folding (e.g. via UPR^mt)	Animal & cell studies promising; translation to humans ongoing.
Reduction of mitochondrial DNA damage	Antioxidant approaches, DNA repair enhancement, possibly mitochondrial gene therapy in future	Mixed results so far; some antioxidant trials have failed or had limited effect. Direct repair, gene therapies are experimental.
Hormonal milieu and sex-steroid support	Sex hormones (e.g. oestrogens, testosterone) have regulatory effects on mitochondrial function; decline in these hormones contributes to mitochondrial decline. Some studies explore this cross‐talk.

Challenges and Cautions

While the prospects are hopeful, there are several challenges:

Complexity and trade-offs

Mitochondrial ROS are not just harmful—they are important signalling molecules. Suppressing ROS too much can impair necessary functions. Likewise, interventions (e.g. high levels of antioxidants) have sometimes failed or even had harm.
Variability among individuals and tissues

Genetic differences, lifestyle, environmental exposures, age, sex all influence mitochondrial function. Organs respond differently. So a one-size-fits-all intervention is unlikely to work optimally.
Limitations of animal models

Much of what we know comes from model organisms (yeast, worms, flies, mice). While many basic mechanisms are shared, human translation is always more complex.
Side effects / safety

Interventions like rapamycin, excessive supplementation, or experimental gene therapies need long-term safety data.
Measuring mitochondrial health

It is difficult to assess mitochondrial function directly in humans in a non-invasive, routine manner. Biomarkers (blood, imaging) exist but are imperfect.

Future Directions

Research is moving in several exciting directions:

Mitochondrial transfer & mitochondrial gene therapy

Studies are exploring whether transferring whole mitochondria, or replacing damaged mtDNA, can rescue function. Still in early stages.
Better biomarkers

Identifying reliable, non-invasive biomarkers of mitochondrial health (e.g. circulating metabolites, imaging) will help both research and personalised interventions.
Precision / personalised interventions

Tailoring strategies by age, sex, genetics, lifestyle. For example, nutritional interventions might need different compositions depending on genetic background or organ vulnerability.
Targeting organ-specific mitochondrial dysfunction

Especially in brain (neurodegenerative disease), heart, skeletal muscle. Interventions may need to be delivered locally or have specific tissue targeting.
Understanding mitochondrial communication and signalling

How mitochondria talk to the nucleus, to immune cells, to other tissues (inter-cellular mitochondrial signals) is increasingly recognised as important. Disruption of communication contributes to systemic aging.
Modulating mitochondrial membrane composition

Altering membrane lipid composition to reduce damage (e.g. reducing susceptibility to peroxidation) may be a strategy. Also understanding how diet affects this.

Practical Tips for Patients

For someone wanting to optimise mitochondrial health (and by extension perhaps improve healthspan / longevity), here are suggestions grounded in current evidence. Always consult with medical professionals before major changes, especially medications or supplements.

Regular physical activity
- Aim for both aerobic (e.g. walking, jogging, swimming) and resistance training.
- Try interval or high-intensity bouts if safe and appropriate—it may improve mitochondrial capacity more.
Dietary pattern
- Consider Mediterranean-style diet: plenty of fruits, vegetables, whole grains, healthy fats (olive oil, nuts), moderate protein, less red/processed meat.
- Minimise processed foods, refined sugars.
- Moderate caloric intake; avoid chronic overeating.
Intermittent fasting / time-restricted feeding
- Even modest fasting windows (e.g. 12-16 hours overnight) may help.
- Ensure nutritional adequacy on feeding periods.
Sleep, stress, environmental exposures
- Sleep is important for mitochondrial repair.
- Chronic stress elevates oxidative stress and may impair mitochondrial function.
- Avoid environmental toxins (e.g. excessive pollution, cigarette smoke) that damage mitochondria.
Consider supplementation / medicine only when needed
- NAD+ precursors (e.g. nicotinamide riboside or mononucleotide) are promising but long-term human data is still emerging.
- Be cautious with antioxidant supplements; more is not always better.
Regular health checks
- Monitor metabolic health (glucose, lipids), cardiovascular health, hormone levels. Dysfunction in these affects mitochondrial stress.

Summary

Mitochondrial function is at the centre of many processes that influence aging and longevity. As we age:

Energy production drops, ROS increases, mtDNA damage accumulates.
Quality control (mitophagy, repair) becomes less efficient.
Nutrient sensing, hormonal signals, cell signalling pathways change in ways that often worsen mitochondrial health.

Yet scientific research also shows clear pathways to improving mitochondrial health: through diet, exercise, maintaining metabolic health, enhancing mitochondrial quality control, and perhaps in future via more advanced therapeutics like mitochondrial transfer or gene therapy. While advances are promising, challenges remain in translation to humans, variability among individuals, and ensuring safety.

Since each person’s ageing process is unique, combining lifestyle approaches with emerging personalised medicine offers the best chance of preserving mitochondrial health, increasing healthspan, and perhaps extending lifespan.

References

Bratic, A., & Larsson, N. G. (2013). The role of mitochondria in aging. Journal of Clinical Investigation. PMC3582127.
Brand, M. D. (2014). The role of mitochondria in longevity and healthspan. Longevity & Healthspan, 3:7.
Sharma, A. et al. (2024). Full article: Mitochondria makeover: unlocking the path to healthy longevity. (Exploring mitochondrial transfer, hallmarks of aging, etc.)
Somasundaram, I. et al. (2024). Mitochondrial dysfunction and its association with age-related decline in physiology. Frontiers in Physiology.
Madreiter-Sokolowski, C. T. et al. (2024). Targeting organ-specific mitochondrial dysfunction to mitigate organ aging.
Xu, X. et al. (2025). Mitochondria in oxidative stress, inflammation, and aging.
Pollicino, F. et al. (2023). Mediterranean diet and mitochondria: New findings.

5 Best Wearables for Longevity

Looking to live longer and healthier? Wearable technology is becoming a powerful tool in the quest for longevity. The right device can help you understand your body, track vital metrics, improve sleep, optimise training, detect potential health problems earlier and support better metabolic control. We explore the five best wearables for longevity available today and explains how we integrate them into your Longevity Plan at CLNQ in Manchester.

Wearables are not medical devices in the strict sense, but many have undergone validation studies and offer clinically relevant insights. When used correctly, they encourage behaviour changes that have a real impact on long-term health.

What Longevity Wearables Can Do

Longevity isn’t about one single factor. It’s the result of maintaining health across multiple pillars: sleep, movement, cardiovascular health, stress management and metabolic stability. The most useful wearables for longevity help you sleep better, move more intelligently, spot problems earlier, maintain tighter glucose control and nudge you into healthier daily habits.

With those principles in mind, let’s explore the five devices I recommend most often for people who want to extend not just their lifespan but their healthspan.

Oura Ring (Gen3)

If you want a device that puts sleep and recovery first, the Oura Ring is one of the best available. Unlike bulky smartwatches, this slim ring design makes it easy to wear at night and throughout the day. It measures heart rate variability, resting heart rate, body temperature, respiratory rate and movement to calculate useful scores for sleep and readiness.

Sleep is a foundation of longevity, and multiple studies have shown that Oura’s sleep data is reliable enough for real-world tracking. The ring helps you understand not just how long you sleep but how restorative that sleep is. Its readiness score is especially valuable for pacing your daily activity, telling you when your body is primed for exertion and when it needs recovery.

Patients often find the Oura Ring more comfortable and less intrusive than wrist-based trackers. Because adherence is so important, this makes it one of the most effective devices for collecting long-term data. At our Longevity Clinic in Manchester, we can often use Oura data to study sleep patterns and identify early warning signs such as changes in temperature or heart rate that may indicate illness or stress.

Apple Watch

The Apple Watch remains the best all-rounder for health and longevity. Its functionality goes far beyond step counting. It offers single-lead ECG recordings, irregular rhythm notifications for atrial fibrillation screening, fall detection, sleep-apnoea notifications and now even hypertension alerts in the latest software update.

The Apple Watch has been evaluated in large studies such as the Apple Heart Study, which demonstrated that its arrhythmia detection features are accurate and clinically useful. For many patients, this can mean earlier detection of atrial fibrillation and a reduced risk of stroke. The new hypertension alerts act as a nudge, encouraging people to confirm their blood pressure with a cuff and seek medical advice.

Another key feature is the sleep-apnoea notification, which can flag the possibility of undiagnosed sleep apnoea. This condition is strongly linked to cardiovascular disease and cognitive decline, so early detection is crucial. The Apple Watch is therefore not just a fitness tracker but also a safety net. At CLNQ we can use Apple Watch data to review your patterns.

Continuous Glucose Monitors

Continuous glucose monitoring is a game-changer for people with diabetes, but it also offers valuable insights for people without diabetes who want to optimise their metabolism. Devices such as the Dexcom G7 and Abbott’s FreeStyle Libre provide real-time glucose data that allows you to see exactly how food, exercise, stress and sleep affect your blood sugar levels.

For those with diabetes, CGM improves time in range, reduces hypoglycaemia and supports better long-term control of HbA1c. For non-diabetics, using a CGM for a few weeks can reveal personal glucose responses to different meals and habits. Patients often report that seeing the data in real time is a powerful motivator to improve their diet and lifestyle choices.

At our clinic, we use CGM in short “metabolic audit” blocks, pairing it with food diaries and lifestyle interventions. This helps patients discover which foods or habits spike their blood sugar and which keep them stable. It provides an immediate feedback loop that drives sustainable changes.

WHOOP

WHOOP is a subscription-based wrist strap designed specifically for tracking recovery, strain and sleep. Unlike other wearables, WHOOP does not have a screen; instead, all the data is viewed in the companion app. This design keeps you focused on insights rather than notifications or distractions.

WHOOP continuously monitors your heart rate, heart rate variability, resting heart rate, respiratory rate, skin temperature and sleep stages. It then translates these into three main scores: Recovery, Strain and Sleep Performance.

From a longevity perspective, WHOOP’s strongest feature is its recovery tracking. By looking at HRV, resting heart rate and sleep quality, it gives a clear picture of whether your body is ready for exertion or whether you should prioritise rest. Over time, this prevents overtraining, supports immune health and encourages consistency in healthy routines.

WHOOP is also valuable for its sleep coaching. The app provides personalised guidance on how much sleep you need based on your recent activity and recovery. For many people, it highlights the importance of sleep debt and how it accumulates, which is a crucial factor in long-term health and resilience.

The main limitation is the subscription model, which locks most of the insights behind a monthly or annual fee. However, for individuals who are serious about training and recovery, the investment can be worthwhile.

At our Longevity Clinic in Manchester, we sometimes recommend WHOOP for patients who want in-depth recovery analysis without the distraction of a smartwatch screen. It pairs well with blood work and lifestyle tracking to give a rounded picture of how the body is adapting over time.

Garmin epix and Forerunner Series

Garmin devices are particularly popular among athletes and active individuals, but they also have significant value for longevity. Models such as the epix Pro and Forerunner 965 track training load, VO₂ max, heart rate variability and recovery time. This helps users balance training intensity with recovery, a crucial aspect of avoiding overtraining and long-term health issues.

These devices are especially useful for guiding a training programme that builds cardiovascular fitness without tipping into chronic stress. For longevity, the goal is sustainable improvement, and Garmin provides some of the most advanced training intelligence available. Long battery life and durable hardware also make them more practical for everyday use.

How We Use Wearables at CLNQ’s Longevity Clinic in Manchester

At CLNQ, we don’t recommend wearables just for the sake of it. Each device is matched to a patient’s goals and medical background. For example, someone struggling with poor sleep may be advised to use the Oura Ring alongside sleep hygiene strategies. Patients at higher cardiovascular risk may benefit more from the Apple Watch’s ECG and blood pressure notifications. Those with metabolic issues may gain valuable insights from short-term CGM use.

The term “wearable stacks,” combines devices to cover multiple areas of health. For example, a patient might use an Oura Ring for recovery, a CGM for glucose insights and an Apple Watch for heart rhythm screening. Every few months we review the data alongside blood tests and body composition analysis to create a comprehensive longevity plan.

Limitations of Wearables

It’s important to note that wearables are not diagnostic tools. They provide screening data and trends but must be interpreted in the context of medical advice. Sleep staging, for example, is useful for identifying trends but not as accurate as a formal sleep study. Similarly, blood pressure alerts should always be confirmed with a medical-grade cuff.

Choosing the Right Wearable

The best wearable depends on your primary goal. If sleep is your priority, the Oura Ring is ideal. If you want a single device for safety and health tracking, the Apple Watch is unmatched. For metabolic insights, a CGM block can be eye-opening. For those focused on fitness, Whoop or Garmin remain good choices.

The key is consistency. A device only benefits you if you wear it regularly and act on its feedback. Data without behaviour change does not improve longevity.

Frequently Asked Questions

Are wearables accurate enough to be useful?

Some features have been validated against medical standards. For example, the Apple Watch ECG is highly accurate for detecting atrial fibrillation, and continuous glucose monitors are proven to improve diabetes control. Sleep tracking is better for trends than for precise staging.

Will a wearable actually help me live longer?

Indirectly, yes. A wearable on its own doesn’t extend life, but it helps you build habits that reduce risk and improve health: better sleep, smarter training, improved metabolic control and earlier detection of disease.

Which is better for sleep tracking, Oura or Apple Watch?

Both work well, but the Oura Ring is designed specifically for sleep and recovery, while the Apple Watch offers broader health features.

Should non-diabetics use continuous glucose monitoring?

Short-term use can be educational and motivating. It is not necessary for everyone, but it can be very helpful for those interested in optimising diet and lifestyle.

Do wearables replace medical care?

No. They are best seen as supportive tools. Abnormal results should always be followed up with professional medical evaluation.

Final Thoughts

The best wearable for longevity is the one you will actually use. For many people, combining devices is the most effective approach. For example, pairing the Oura Ring for sleep with the Apple Watch for heart monitoring and a CGM for short-term metabolic insights gives a rounded picture of health.

At our Longevity Clinic in Manchester, we help patients choose and integrate the right devices, review their data, and combine it with blood testing, nutrition advice and advanced therapies. The result is a personalised programme that turns numbers into longer, healthier years.

DAO Botox

DAO Botox: Lift Downturned Mouth Corners Safely and Subtly in Manchester

If the corners of your mouth naturally pull down, you may feel you look tired, stern or “sad” even when you’re perfectly content. This expression is often driven by overactivity of a small pair of muscles called the depressor anguli oris (DAO). Precisely placed anti-wrinkle injections (commonly known as Botox®) can relax these muscles, allowing the mouth corners to rest in a more neutral or slightly lifted position. At our Botox clinic in Manchester, we perform DAO treatments as a refined, low-downtime option to refresh the lower face without altering your natural character.

We explain what DAO Botox is, who it’s suitable for, how treatment works, what results to expect, and the risks to be aware of—written in plain English with the essential medical detail you’d expect from an experienced plastic surgery-led clinic.

What is the DAO muscle?

The DAO (depressor anguli oris) is a triangular muscle on each side of the lower face. It arises from the lower jaw (mandible) and inserts into the corner of the mouth (oral commissure). Its main job is to pull the mouth corner downwards, working in concert with other lower-face depressor muscles (like depressor labii inferioris and parts of the platysma).

When the DAO is comparatively stronger than the upper lip elevators and zygomatic muscles (the ones that lift and smile), you may see persistent downturning at rest. With age, volume loss in the chin and jawline, skin laxity and repeated expressions can accentuate this. The visual effect is the classic “sad mouth” and, over time, marionette lines (creases from the corners down towards the chin).

What is DAO Botox?

DAO Botox involves micro-doses of botulinum toxin type A injected into the DAO on each side to reduce its pull. By easing the downward force, the mouth corners are no longer dragged south, so the face looks softer, less stern and more approachable. It’s a quick, minimally invasive procedure with no cutting, no stitches and no significant downtime.

Botulinum toxin temporarily interferes with acetylcholine release at the neuromuscular junction, weakening the targeted muscle for 3–4 months on average. In the DAO, we aim for selective relaxation, not a frozen look. Precise placement and conservative dosing are the keys to natural results.

Who is a good candidate?

You might be suitable for DAO Botox if you:

Notice downturned mouth corners at rest that make you look sad or cross.
See early marionette lines but aren’t ready for surgery or dermal fillers alone.
Want a subtle lift to the mouth corners without changing your fundamental smile.
Have good general health, realistic expectations and understand the temporary nature of toxin treatments.

Caution/relative contraindications include:

Pregnancy or breastfeeding (we avoid elective toxin treatments).
Active infection or skin irritation at injection sites.
Certain neuromuscular conditions (e.g., myasthenia gravis).
Known allergy to any component of the product.
Significant lower-face laxity or deep volume loss that might be better addressed with fillers, threads, skin tightening or surgery—or in combination.

Why choose our doctor-led Botox clinic in Manchester?

DAO treatment sits at the intersection of fine anatomy and facial aesthetics. Small placement errors can affect smile mechanics, lip competence or speech. At our Manchester clinic, injections are performed by experienced medical professionals with deep knowledge of facial musculature and balanced smile dynamics. You get:

Individual assessment of your smile, lip mobility, dental show and chin support.
A conservative, step-wise dosing plan to keep results natural.
Honest advice on adjunct treatments (e.g., mentalis or marionette fillers) to achieve the best overall outcome.
Aftercare and review built into your plan, so we can fine-tune if needed.

Treatment goals and what results to expect

The goal is softening of the downward pull, giving a neutral to slightly elevated oral commissure. Expect:

Subtle lift at the corners rather than a dramatic “pout” or stretched look.
Improvement in a perennially stern or sad expression.
Secondary softening of the early marionette fold as downward tension eases.

Onset is gradual: a light effect from day 3–5, with peak results around 10–14 days. Most people enjoy results for 3–4 months; some get longer, some a little less, depending on metabolism, dose and muscle strength. Many patients choose quarterly maintenance to keep the look steady.

What happens during consultation?

Medical history & goals – We discuss your concerns, medical background, and any prior injectables.
Dynamic assessment – We watch your resting face and expressions (smile, talk, frown), feel for muscle bulk, and assess lip competence, mentalis activity (chin dimpling), and platysma pull.
Plan & expectations – We outline if DAO Botox alone will suffice or whether to combine with fillers for marionette shadows or mentalis toxin for chin puckering.
Informed consent – We cover benefits, limitations, and risks.
Photography – Standardised images for your records and to track results.

How DAO injections are performed

We cleanse the skin and mark the safe injection zone—usually over the DAO belly, lateral to midline structures and superficial enough to target DAO while avoiding deeper lip depressors.
Most people don’t need numbing; injections feel like tiny pinpricks and take 5–10 minutes.
We use micro-doses spread across one or two points per side to achieve even relaxation.
You can return to normal activities immediately, avoiding heavy exercise, heat exposure or facial massages for the rest of the day.

Important: DAO dosing must avoid diffusion into the depressor labii inferioris (DLI), which helps lower and evert the lower lip. Inadvertent DLI weakening can cause lower-lip asymmetry or difficulty showing lower teeth. Experienced placement keeps this risk low.

Typical dosing and personalisation

Because anatomy and muscle strength vary, dosing is individualised. Many clinicians use small, conservative units per side initially, then review at two weeks for a top-up if needed. People with stronger DAO activity or heavier lower-face tissues may need slightly higher total doses to achieve a balanced effect. The art lies in treating enough to soften the downturn while preserving natural expression.

Combining DAO Botox with other treatments

DAO treatment often works best as part of a lower-face harmony plan:

Marionette line fillers (hyaluronic acid) to correct shadows once downward pull is reduced.
Mentalis Botox to relax chin dimpling and reduce upward chin contraction that can worsen marionette folds.
Chin and prejowl contouring with filler to support the mouth corners and improve jawline definition.
Lower-face skin tightening (e.g., radiofrequency microneedling) for mild laxity.
Nefertiti lift (platysma toxin) in selected cases where neck bands pull the jawline down, always with caution to maintain functional strength.

A staged approach is often optimal: DAO first, review at 2 weeks, then add filler or skin treatments once the new muscular balance is established. This sequencing helps us use less product more precisely.

Safety, side effects and downtime

DAO Botox is well-tolerated. Common, short-lived effects include:

Pinpoint redness or swelling at the injection site (minutes to hours).
Mild tenderness or a small bruise.
A brief feeling of asymmetry as the toxin takes effect (resolves as both sides settle).

Uncommon but important risks:

Smile or lip asymmetry if toxin affects adjacent muscles like the DLI. Usually temporary, improving as the toxin wears off.
Feeling the lower lip is weaker when trying to depress or evert it.
Less commonly, dysarthria (subtle speech change) or drooling if diffusion is excessive—again, temporary.

Choosing a skilled medical injector and using conservative doses drastically reduces these risks. If a minor imbalance occurs, it can sometimes be balanced with small adjustments rather than waiting it out.

Aftercare in brief

Avoid rubbing or massaging the area for the rest of the day.
Skip saunas, hot yoga, and strenuous exercise for 24 hours.
Stay upright for 3–4 hours after treatment.
Make gentle expressions, but don’t “overwork” the area deliberately—there’s no evidence it helps uptake.
Review with us at two weeks to check symmetry and fine-tune if needed.

How long does it last?

Most patients enjoy a smoother, softer mouth corner position for 3–4 months. First-timers sometimes metabolise a little faster initially. With consistent maintenance at our CLNQ Manchester Botox clinic, we can keep your lower face looking naturally positive all year round.

DAO Botox vs dermal fillers vs surgery

DAO Botox relaxes downward pull—great for expression-driven downturn with relatively early marionette changes.
Dermal fillers rebuild volume and support, softening folds and lifting the corners structurally.
Threads or skin tightening can modestly redrape mild laxity.
Surgical options (e.g., corner lip lift, facelift/mini-lift) address significant laxity, descent or deep folds and provide longer-lasting change.

Often, a blend of DAO Botox plus carefully placed filler gives the best non-surgical outcome.

Your next step

If downturned corners are making you look more serious than you feel, a precise DAO treatment may be the smallest change that makes the biggest difference. Book a consultation at our Botox clinic in Manchester to assess your smile dynamics and design a plan that keeps you looking like you—just fresher.

Frequently Asked Questions about DAO Botox

Will DAO Botox change my smile?

The aim is to soften the downward pull without flattening your smile. With skilled placement and conservative dosing, your smile should look more relaxed, not frozen. A short review at two weeks lets us fine-tune if needed.

How many units do I need?

It varies. We tailor dose to muscle strength and facial balance. Many patients start with small, conservative amounts per side and adjust at review for a natural result.

Is DAO Botox painful?

Most people describe brief pinpricks. The procedure is very quick and usually doesn’t require numbing.

How soon will I see results?

Expect early changes by day 3–5, with peak effect at 10–14 days.

How long do results last?

Typically 3–4 months. Regular maintenance helps keep results consistent.

What are the risks?

Minor redness or bruising is the most common. Less commonly, lip asymmetry or temporary lower-lip weakness can occur if adjacent muscles are affected. Choosing an experienced injector minimises these risks.

Can DAO Botox be combined with filler?

Yes. It’s often ideal to combine DAO Botox with marionette line or chin filler for comprehensive lower-face rejuvenation.

Who should avoid treatment?

We avoid Botox in pregnancy and breastfeeding, active skin infection, and certain neuromuscular disorders. We’ll review your medical history to keep you safe.

Will people be able to tell?

Most patients get comments like “You look rested” rather than “What have you done?”. The change is subtle and natural.

What if I don’t like the result?

Botulinum toxin wears off gradually. Minor imbalances can sometimes be adjusted; otherwise, effects fade over several weeks.

Ready to feel more like yourself?

Book a consultation at our Botox clinic in Manchester or our Cheshire site to discuss whether DAO Botox is the right choice for you. We’ll tailor a plan to your unique anatomy and goals so you look calm, kind and confident—without anyone pinpointing why.

Ozone Therapy for Skin Disease

If you’re searching for gentle, science-informed ways to calm inflamed skin, speed healing and support a clearer complexion, ozone therapy for skin disease is worth understanding. At our longevity clinic in Manchester and Cheshire, we use medical-grade ozone in carefully controlled ways to help the skin fight microbes, reduce oxidative stress over time (by up-regulating your own antioxidant enzymes), and nudge tissue repair. We explains what ozone therapy is, how it works for skin, who it may help, safety points, what a course at CLNQ might involve, and the evidence to date from peer-reviewed sources.

What is medical ozone therapy?

Medical ozone is a precise mixture of ozone (O₃) and oxygen (O₂) produced by a certified medical generator. Unlike the raw environmental gas, medical ozone is delivered at controlled concentrations for specific therapeutic aims, and never inhaled. In dermatology and skin-health settings, it is typically used in three main ways:

Topically, via ozonated oils (e.g., ozonated olive oil) or ozonated water/solutions applied to the skin.
Local gas exposure (“bagging”), where an affected limb or area is enclosed and exposed to ozone gas at a set concentration for a set time (with strict ventilation and scavenging).
Systemic approaches (e.g., autohaemotherapy) used in broader longevity/immune protocols—sometimes considered where skin disease is part of a wider inflammatory picture. These are outside the scope of purely topical skin care but may be relevant in select cases after medical assessment.

At CLNQ’s Longevity Clinic in Manchester, our ozone protocols include iv ozone therapy to support dermatological indications.

How does ozone help the skin?

In small, controlled doses, ozone acts like a therapeutic signal. It briefly generates reactive oxygen species (ROS) at the skin surface which triggers adaptive responses: your cells up-regulate antioxidant enzymes (e.g., superoxide dismutase, catalase, glutathione peroxidase) and pro-repair pathways (including Nrf2 activation). That “short-term challenge” can improve resilience and tissue oxygen handling. In addition, ozone has broad antimicrobial activity against bacteria, fungi and some viruses, helping with infection-prone conditions and biofilms.

Key skin-relevant mechanisms described in the literature include:

Antimicrobial action: Ozone disrupts microbial cell walls and viral envelopes, helping to control P. acnes (C. acnes), Staphylococcus aureus, candida/dermatophytes, and mixed wound flora.
Biofilm disruption: Useful where chronic wounds or follicular blockage involve biofilms that resist antibiotics and antiseptics.
Improved microcirculation and oxygen utilisation: By modulating red-cell 2,3-DPG and local nitric oxide signalling, tissues may receive and use oxygen more efficiently—supporting repair.
Immunomodulation: Ozone can reduce excessive inflammatory signalling while promoting a pro-healing milieu, which is relevant for chronic inflammatory dermatoses.
Pro-repair signalling: Low-dose oxidative “conditioning” can cue fibroblasts and keratinocytes to migrate and proliferate, aiding epithelialisation in wounds and post-procedure healing.

In short: clean the area, calm the inflammation, and cue repair—that’s the triple benefit we’re aiming for when we use ozone carefully for skin problems.

Which skin conditions might benefit?

Evidence is emerging and still growing. In our clinic we position ozone therapy as an adjunct—something that can enhance standard care and aesthetic protocols, not necessarily replace them.

Acne (comedonal and inflammatory)

Topical ozonated oils and local ozone applications can reduce bacterial load and surface biofilms while calming inflamed papules and pustules. We often combine ozone with gentle medical facials, light-based therapy and targeted topicals. Patients typically report the skin feels cleaner, less oily and less inflamed within a few sessions.

Eczema/dermatitis (adjunctive care)

For atopic dermatitis or nummular eczema, ozone’s antimicrobial and barrier-supporting effects (through lipid peroxidation products converted to more stable ozonides in ozonated oils) may reduce secondary colonisation (e.g., S. aureus) and improve comfort. We emphasise barrier repair alongside ozone—ceramide-rich emollients, trigger control, and, when needed, prescription therapies.

Psoriasis (adjunctive care)

Psoriasis is immune-driven and often stubborn. While ozone is not a cure, it can be soothing for plaques, help with scaling and micro-fissures, and may support remissions when used as part of a broader plan (vitamin D analogues, biologics where appropriate, metabolic optimisation in a longevity framework).

Fungal skin and nail issues

Ozone’s antifungal effects can assist with tinea (athlete’s foot, ringworm) and support nail-unit hygiene for onychomycosis, particularly when used with mechanical debridement and, where indicated, pharmaceutical antifungals.

Wound care & post-procedure healing

There’s promising data for chronic wounds, ulcers, and postoperative incisions, where controlled local ozone reduces bioburden and supports granulation and epithelialisation. In aesthetics, we may use topical ozone to help calm and hygienically support the skin after procedures such as microneedling, subcision, or minor lesion removal.

Herpetic lesions (adjunct)

Ozone’s virucidal and immunomodulatory actions may help reduce the viral load at the surface and support faster crusting/resolution when combined with antiviral medicines.

What does the clinical evidence say?

High-quality, large randomised trials are still limited, but systematic reviews and controlled studies in dermatology suggest ozone therapy is effective and safe as an adjunct for several skin indications:

A systematic review of ozone therapy in dermatology reports improvements in wound healing, infectious dermatoses and inflammatory conditions, with a favourable safety profile when medical protocols are followed.
Clinical studies on ozonated oils show reductions in microbial counts and improvements in lesion scores in acne and infected eczema, with good tolerability.
Trials in diabetic foot ulcers and chronic wounds (not purely cosmetic, but skin-healing relevant) show enhanced healing rates and less infection, supporting the pro-repair and antimicrobial rationale.

Safety: what you need to know

Medical ozone is safe when used correctly by trained doctors in a CQC registered clinic such as CLNQ in Manchester:

Never inhale ozone gas. Treatments are topical/local with proper scavenging or performed via ozonated liquids/oils.
Concentration and exposure time are critical. We use medical generators and protocols tailored to the indication (measured in μg/mL; dose = concentration × time × exposed surface).
Typical side-effects are mild and transient: temporary tingling, warmth, dryness or mild erythema at the site. A brief “purge” in acne can occur as the skin resets.
Contraindications/cautions (we screen for these):
- G6PD deficiency (risk of haemolytic stress)
- Uncontrolled hyperthyroidism
- Severe anaemia or active major bleeding
- Pregnancy (relative caution for elective treatments)
- Severe uncontrolled asthma or COPD where inadvertent inhalation would be risky
- Any active dermatological emergency that needs urgent medical or surgical treatment
Drug interactions: Few direct interactions are noted with topical/local use, but we review your medicines, especially if you’re on immunosuppressants, systemic retinoids, or photosensitisers, to time treatments sensibly.

At CLNQ, every patient receives a medical consultation so we can weigh benefits and risks and plan a sensible course.

Ozone therapy at CLNQ Longevity Clinic Manchester

Step 1: Skin assessment

We examine the skin, your diagnosis (or arrange one if needed), recent flare pattern, triggers, microbiome stressors, and barrier health. In complex cases (e.g., refractory acne, recurrent infections, non-healing wounds) we may coordinate with your GP/dermatologist or run supporting investigations (vitamin D, iron, HbA1c, thyroid, microbiology where relevant).

Step 2: Personalised ozone protocol

We match the delivery to the condition:

Acne/folliculitis:
- Ozonated water cleanse → local ozone exposure (bagging/hood) for problem zones → ozonated oil as a home adjunct.
- Combine with non-comedogenic skincare, LED light therapy and, if indicated, prescription topicals.
Eczema/dermatitis:
- Short, gentle local ozone to reduce colonisation, followed by barrier-repair emollients.
- Trigger coaching (fragrance, detergents, sweat, wool, stress), and medical therapy as needed.
Psoriasis:
- Targeted local ozone for plaques plus keratolytics/emollients; consider systemic/longevity optimisation (weight, insulin resistance, vitamin D) in conjunction with your specialist plan.
Fungal/tinea/onychomycosis:
- Local ozone to skin and nails, adjunctive debridement, ozonated oil between sessions; footwear and moisture advice.
Wounds/post-procedure:
- Local ozone after cleansing to decrease bioburden and support granulation, then sterile dressings and post-op aftercare.

Step 3: Session rhythm

Frequency: Typically 1–2 sessions per week initially, then taper as the skin stabilises.
Duration: 15–30 minutes per area per session, depending on the protocol.
Course length: Many people notice benefits within 3–6 sessions, while chronic conditions may require 6–12+ sessions with maintenance.

Step 4: Combining with longevity care

Because many skin conditions are systemic-inflammatory or barrier-metabolic in nature, we can integrate ozone with broader longevity strategies: sleep, stress, nutrition (including omega-3s and micronutrients), vitamin D optimisation, light-based therapies, and, where appropriate, adjuncts such as hyperbaric oxygen therapy or photobiomodulation. The goal is healthier skin that lasts, not just a quick fix.

Who is a good candidate?

You have acne, eczema, psoriasis, recurrent folliculitis, fungal skin issues, or slow-to-heal skin and want a non-drug adjunct to amplify your results.
You prefer evidence-led, minimally invasive approaches delivered by medical professionals.
You’re willing to follow a complete plan—skincare, triggers, lifestyle—and attend a course of treatments rather than a one-off.

If your condition is severe, rapidly worsening, or atypical, we’ll prioritise further medical work-up before starting.

Benefits you can realistically expect

Calmer, cleaner skin as bioburden reduces
Fewer inflammatory lesions (acne) and less itch (eczema)
Faster healing after minor procedures or in chronic wounds
Improved comfort and barrier function, with better tolerance of active skincare
Low downtime, with treatments that are quick and well-tolerated

As always, results vary—your skin biology, adherence, and any underlying conditions play a role.

Aftercare and home support

Keep it simple: gentle, fragrance-free cleanser; ceramide-rich moisturiser; non-comedogenic SPF.
Use ozonated oil as advised between sessions for hygiene and micro-support without stripping the barrier.
Avoid harsh actives (e.g., strong retinoids, high-strength acids) for 24–72 hours after sessions unless we advise otherwise.
Nourish from within: adequate protein, omega-3s, and vitamin D; go easy on ultra-processed foods and high-glycaemic spikes.
Track triggers: sweat, friction, stress, lack of sleep—address what you can.

Why choose CLNQ for ozone therapy in Manchester & Cheshire?

Medical Doctor-led: Treatments led by experienced doctors with strict protocols and medical-grade equipment.
Personalised longevity plans: We treat skin as part of your whole-body health—improving the terrain that drives flare-ups.
Integrated care: From medical facials and light therapy to post-procedure support and wound care, we tailor your pathway.
CQC Registered Clinic: Our clinics are CQC registered which means they are regulated medical clinics and our recent inspection had a ‘Good’ rating.

Frequently Asked Questions

Is ozone therapy safe for skin?

Yes—when delivered with medical-grade equipment and proper protocols, ozone therapy for skin is generally well-tolerated. The gas is not inhaled, and we use concentrations and exposure times tailored to your indication. Mild, temporary redness or dryness can occur.

Can ozone therapy treat acne?

It can help as an adjunct by reducing C. acnes load and calming inflammation. We often combine ozone with skincare, LED/light therapy, and, when indicated, prescription treatments. Many patients notice fewer breakouts and quicker resolution of active lesions over a short course.

What about eczema or psoriasis?

Ozone can reduce colonisation (e.g., Staph on eczema skin) and support barrier repair. In psoriasis, it may soothe plaques and aid scaling control as part of a broader plan. It is not a cure, but it often improves comfort and appearance when correctly integrated.

How many sessions will I need?

For acne or infected eczematous patches, expect an initial block of 3–6 sessions over a few weeks. Chronic or nail-unit issues often need 6–12+ sessions. We’ll review and adjust based on your response.

Is there downtime?

Minimal. You can usually return to daily activities immediately. We advise gentle skincare for 24–72 hours after a session.

Who should avoid ozone therapy?

People with G6PD deficiency, uncontrolled hyperthyroidism, severe anaemia, or those who are pregnant (for elective therapies) should avoid or delay treatment. We’ll screen you during consultation.

Can I combine ozone with other treatments?

Yes. We frequently combine ozone with medical facials, LED/light therapy, microneedling aftercare, wound support, and standard dermatology treatments. It’s a complement, not a replacement.

How much does ozone therapy cost in Manchester?

Pricing depends on the area treated and course length. Please contact CLNQ for current fees and package options.

Book a consultation

If you’re considering ozone therapy for skin disease in Manchester, our longevity-focused doctors will assess your skin, tailor a plan, and guide you through a safe, effective course. Get in touch to start a personalised programme for calmer, healthier skin.

References

PubMed (2022/2023) – Clinical insights into ozone therapy mechanisms and dermatological applications. PubMed ID: 36527235
PMC Review – Comprehensive overview of medical ozone’s biochemical effects, antimicrobial action, and clinical uses in skin conditions. Open-access article: PMC9122276
Indian Journal of Dermatology (2022) – “Effectiveness and safety of ozone therapy for dermatological diseases”: review of indications, outcomes, and adverse events. Journal link: LWW/IJD

What is Creatine?

Creatine is a naturally occurring compound that your body produces from amino acids, mainly in the liver and kidneys. It is stored in your muscles and brain, mostly as phosphocreatine, which acts like an energy reserve. When your body needs quick energy for short bursts of activity, phosphocreatine helps recycle ATP, the main energy currency of the body.

This means creatine plays an important role in powering activities such as sprinting, climbing stairs, or lifting heavy weights. It also supports the brain during periods of high energy demand.

You get around 1–2 grams of creatine each day through food, mainly from red meat and fish. By taking creatine as a supplement, you can increase your muscle and brain creatine stores beyond what diet alone can achieve. This can be especially helpful for vegetarians, vegans, and older adults who usually have lower baseline creatine levels.

How Does Creatine Work?

Creatine works by increasing the body’s phosphocreatine stores, which helps the muscles regenerate ATP more quickly. This means you can push harder and for longer during short, intense exercise.

At a cellular level, creatine may also play a role in supporting protein synthesis and reducing exercise-related inflammation and muscle damage. These mechanisms are still being studied, but they help explain why creatine is so effective for physical performance and potentially for wider health benefits.

Evidence-Based Benefits of Creatine

Strength and Training Performance

One of the most reliable benefits of creatine is its ability to improve high-intensity exercise performance. By allowing you to complete more repetitions or lift slightly heavier weights, creatine improves the overall quality of training. Over time, this can lead to better results in terms of strength and endurance.

Healthy Ageing and Muscle Loss

As we age, we naturally lose muscle mass and strength, a process known as sarcopenia. This increases the risk of falls and reduces independence. Research shows that creatine supplementation, especially when combined with resistance training, can help older adults maintain muscle mass, strength, and functional capacity. There is also evidence that creatine may reduce inflammation and support bone health.

Women’s Health

Creatine may be particularly beneficial for women, as changes in hormones across the menstrual cycle and during menopause affect energy metabolism. Studies suggest creatine is safe for women and may support strength and training performance. It could also help during menopause when shifts in energy balance make maintaining strength and muscle more difficult.

Brain and Cognitive Performance

The brain consumes a lot of energy, and creatine may help by improving ATP recycling during demanding mental tasks. Early studies suggest creatine may improve aspects of working memory and processing speed, particularly under stress, such as during sleep deprivation. However, effects are variable and not guaranteed.

What Creatine Cannot Do

Despite the hype, creatine is not a magic pill. It does not guarantee muscle growth without training. Some people, known as “non-responders,” may see little benefit, especially if they already have high baseline creatine levels from diet.

There is also no conclusive evidence that creatine prevents neurodegenerative diseases or significantly slows ageing, although research is ongoing. Finally, creatine does not burn fat. In fact, some people may notice a slight increase in body weight from increased water retention in the muscles.

Is Creatine Safe?

For most healthy adults, creatine monohydrate is safe when taken at the recommended doses. However, people with kidney or liver problems, diabetes, or bipolar disorder should avoid creatine unless advised otherwise by a doctor. Safety in pregnancy and breastfeeding has not been established, so it should not be taken unless prescribed by a clinician.

Large studies and reviews show no greater risk of adverse effects compared with placebo. Minor side effects such as bloating or diarrhoea can occur, especially with high doses, but these are usually avoidable by splitting the dose and taking creatine with food.

Common Side Effects and Myths

The most common side effect of creatine is a slight increase in body weight due to water being drawn into muscle cells. This is not fat gain and often levels out over time.

Some people may experience digestive upset if they take too much creatine at once. Splitting the daily dose into two or three smaller servings can reduce this.

There have been claims that it causes hair loss, but the evidence is very weak and not supported by large-scale studies. Similarly, despite concerns, there is no strong evidence that creatine harms healthy kidneys when taken correctly.

Best Form of Creatine

The best and most studied form of creatine is creatine monohydrate. Other forms, such as creatine hydrochloride or ethyl ester, have not been shown to be more effective. Creatine monohydrate is also the most affordable and widely available.

How to Take Creatine

There are two main approaches:

Steady daily dose: Take 3–5 grams daily. Muscle stores reach full saturation after 3–4 weeks.
Loading phase: Take 20 grams daily, divided into 4 doses, for 5–7 days. After this, continue with 3–5 grams daily. This saturates muscles more quickly but increases the risk of stomach upset.

Timing is flexible. Many people take it after exercise or with a meal, but the key is consistency. Hydration is important, but there is no need to over-hydrate.

Who Benefits Most from Creatine?

Athletes and regular exercisers who want to improve performance.
Older adults looking to reduce muscle loss and falls risk.
Vegetarians and vegans, who usually have lower creatine levels from diet.
Women, particularly during menopause, when maintaining muscle and strength is harder.
People under high mental or physical stress, such as students during exams or shift workers.

Creatine and Longevity Clinics

At our Manchester Longevity Clinic, it is not used in isolation. It forms part of a structured health programme that also includes strength training, good nutrition, and regular monitoring.

Our holistic approach may include:

A health review and blood tests.
A personalised longevity plan.
Ongoing monitoring of overall health.

Anti-Ageing Claims – The Reality

It has been called “anti-ageing” in the media because of its effects on muscle and possibly the brain. While early studies in animals suggest creatine may reduce oxidative stress and support mitochondrial function, these findings have not yet been proven in long-term human studies.

What we can say with confidence is that creatine supports healthy ageing by helping maintain muscle, bone strength, and function—especially when combined with exercise.

Practical Tips for Taking Creatine

Choose simple creatine monohydrate powder from a trusted brand.
Start with 3 grams daily, then increase to 5 grams if well tolerated.
Skip the loading phase if you are prone to bloating.
Take it at the same time each day to build a habit.
Pair it with regular resistance training for maximum benefit.
Check with your doctor if you have kidney, liver, or other medical conditions.

Frequently Asked Questions

Is it safe to take long-term?

Yes, for most healthy adults. Studies show it is safe when taken at recommended doses. People with kidney or liver problems should seek medical advice before taking it.

Will creatine make me fat or bloated?

Creatine does not cause fat gain. Some people experience temporary water retention in the muscles, which can make them feel slightly fuller.

Should older adults take creatine even if they don’t exercise?

Creatine works best when combined with strength training. Without exercise, the benefits are limited.

Is creatine good for women?

Yes. Research shows it is safe and effective for women, and it may be especially useful around menopause.

Does creatine help the brain?

It may support mental performance under stress, such as during sleep deprivation, but results vary and more studies are needed.

Do I need a loading phase?

No. A loading phase is optional. A steady daily dose works just as well over time.

Final Thoughts

Creatine is one of the most effective and well-studied supplements available. It has proven benefits for physical performance, muscle strength, and healthy ageing, and emerging evidence suggests possible benefits for brain function.

At our CLNQ Longevity Clinic, creatine is used as part of a personalised programme that combines nutrition, exercise, and medical support. If you are interested in adding creatine to your health plan, our team can help you do so safely and effectively.

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What Is Glutathione?

How Does Glutathione Affect the Skin?

1. Skin Brightening and Pigmentation Control

2. Powerful Antioxidant Protection

3. Anti-Ageing and Collagen Support

4. Detoxification and Skin Clarity

What Does Science Say About Glutathione for Skin?

How Can You Boost Glutathione Levels?

1. Dietary Sources

2. Oral Supplements

3. IV Glutathione Therapy

4. Topical Glutathione Formulas

Who Can Benefit from Glutathione?

Is Glutathione Safe?

Glutathione at CLNQ

Key Benefits of Glutathione for Skin Health

The CLNQ Approach to Skin Longevity

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FAQs About Glutathione for Skin Health

What is red light therapy?

Why consider red light therapy after surgery?

1) Supports wound healing